Peng Hongbin, Wang Xiaoxia, Liao Ying, Lan Lichong, Wang Danni, Xiong Yaohuan, Xu Ling, Liang Yinxia, Luo Xia, Xu Yunan, Li Feiyan, Chen Hao, Ning Chuanyi
School of Nursing, Guangxi Medical University, Nanning, China.
College & Hospital of Stomatology, Guangxi Medical University, Nanning, China.
Front Public Health. 2025 Mar 18;13:1484223. doi: 10.3389/fpubh.2025.1484223. eCollection 2025.
While the correlation between cancer and air pollutants is well-established, research on the delayed effects of NO on oral cancer remains limited.
We collected data on nitrogen dioxide (NO) along with diagnosed cases of oral cancer in Guangxi, China, and analyzed the correlation between exposure to NO and the prevalence of oral cancer.
The study included 1,841 participants diagnosed with oral malignancies, consisting of 1,179 males (64.0%) and 662 females (36.0%), with a mean age of 55.9 ± 14.0 years. The NO concentration is 20.2 ± 10.4 μg/m. The highest cumulative effects of NO exposure were observed at a 3-year cumulative lag, with a relative risk (RR) of 1.115 (95% CI: 1.102-1.128). For males, the most pronounced effect of NO also occurred at a 3-year lag (RR = 1.110, 95% CI: 1.094-1.127). Similarly, among females, the significant cumulative impact of NO was found at a 3-year lag (RR = 1.123, 95% CI: 1.101-1.145). For individuals under 60 years of age, the cumulative impact of NO peaked at the same 3-year lag (RR = 1.102, 95% CI: 1.085-1.120). For individuals aged 60 and above, the highest cumulative impact of NO was also detected at a 3-year lag (RR = 1.132, 95% CI: 1.112-1.152). For the group with normal BMI, the highest cumulative effect of NO exposure was also observed at the 3-year lag period (RR = 1.289, 95% CI: 1.217-1.365), consistent with the findings for other groups.
These findings suggest a significant lagged effect of long-term NO exposure on oral cancer, with varying associations between NO and oral cancer across different ages and genders.
虽然癌症与空气污染物之间的关联已得到充分证实，但关于一氧化氮（NO）对口腔癌的延迟影响的研究仍然有限。
我们收集了中国广西二氧化氮（NO）的数据以及口腔癌确诊病例，并分析了NO暴露与口腔癌患病率之间的相关性。
该研究纳入了1841名被诊断为口腔恶性肿瘤的参与者，其中男性1179名（64.0%），女性662名（36.0%），平均年龄为55.9±14.0岁。NO浓度为20.2±10.4μg/m。在3年累积滞后时观察到NO暴露的最高累积效应，相对风险（RR）为1.115（95%置信区间：1.102 - 1.128）。对于男性，NO的最显著效应也出现在3年滞后时（RR = 1.110，95%置信区间：1.094 - 1.127）。同样，在女性中，NO的显著累积影响在3年滞后时被发现（RR = 1.123，95%置信区间：1.101 - 1.145）。对于60岁以下的个体，NO的累积影响在相同的3年滞后时达到峰值（RR = 1.102，95%置信区间：1.085 - 1.120）。对于60岁及以上的个体，NO的最高累积影响也在3年滞后时被检测到（RR = 1.132，95%置信区间：1.112 - 1.152）。对于体重指数（BMI）正常的组，NO暴露的最高累积效应也在3年滞后期被观察到（RR = 1.289，95%置信区间：1.217 - 1.365），与其他组的结果一致。
这些发现表明长期NO暴露对口腔癌有显著的滞后效应，不同年龄和性别的NO与口腔癌之间存在不同的关联。
