Lang B, Roberts A J, Vincent A, Newsom-Davis J
Clin Exp Immunol. 1985 Jun;60(3):637-44.
Anti-idiotype sera, raised in rabbits against anti-acetylcholine receptor (AChR) (idiotype) purified from the serum of three myasthenia gravis patients, inhibited binding of homologous idiotype to the AChR by up to 80%. The expression of idiotype in the three individuals changed very little over a period of several years, during which they showed a declining trend in overall anti-AChR antibody. Only one of the four anti-idiotype sera inhibited the binding of anti-AChR from a number of other patients. Our results indicate a consistency of idiotype expression within an individual, and fail to show substantial idiotype sharing between individuals.
用从三名重症肌无力患者血清中纯化的抗乙酰胆碱受体（AChR）（独特型）免疫家兔制备的抗独特型血清，可使同源独特型与AChR的结合抑制率高达80%。在数年时间里，这三名个体的独特型表达变化很小，在此期间他们的抗AChR抗体总体呈下降趋势。四份抗独特型血清中只有一份能抑制其他多名患者的抗AChR的结合。我们的结果表明个体内独特型表达具有一致性，且未显示个体间存在大量独特型共享。
