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竖脊肌平面阻滞对脊柱手术术后恢复质量的影响:一项系统评价和荟萃分析

Impact of erector spinae plane block on postoperative recovery quality in spinal surgery: a systematic review and meta-analysis.

作者信息

Zhang Longyi, Zhou Xuelei, Chen Linlin, Liu Xianchun, Mao Wei, Zhao Li, Li Linji, Xie Ying

机构信息

The Second Clinical Medical College, North Sichuan Medical College, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong City, Sichuan Province, China.

出版信息

Eur Spine J. 2025 Apr 3. doi: 10.1007/s00586-025-08810-3.

Abstract

BACKGROUND

Postoperative recovery quality (QoR) is a key indicator for evaluating the restoration of patients' functional status and overall quality of life post-surgery. Moreover, it is an essential metric for assessing the effectiveness of patient-centered anesthetic care. The erector spinae plane block (ESPB) is an innovative regional analgesia technique that has garnered considerable attention for its potential use in spinal surgeries. Although some studies suggest that ESPB may improve QoR, the results remain contentious and inconclusive. This meta-analysis aims to systematically evaluate the effects of ESPB on the subjective quality of recovery in patients undergoing spinal surgery, with the objective of providing more robust evidence to support its clinical application.

METHODS

On September 23, 2024, we conducted a systematic search across the PubMed, Embase, Web of Science, Cochrane Library, and Scopus databases to identify randomized controlled trials (RCTs) relevant to ESPB. The studies evaluated the effect of ESPB compared to conventional analgesia on QoR in patients undergoing spinal surgery. The primary outcome measure of this study was postoperative the 24-hour QoR score, as assessed by validated QoR scales (QoR-15 and QoR-40). Secondary outcome measures included the QoR score at 48 h postoperatively, the incidence of postoperative nausea and vomiting (PONV), and the consumption of opioid analgesics in the first 24 h postoperatively.

RESULTS

This meta-analysis included eight studies, with a total of 578 patients. The results demonstrated that, compared to the control group, the ESPB group showed improvements in overall QoR-15 scores (mean difference [MD]: 9.76; 95% confidence interval [CI]: 8.39-11.13; P < 0.01; I² = 0%) and QoR-40 scores (MD: 11.8; 95% CI: 6.35-17.25; P = 0.000), indicating clinically meaningful benefits. Additionally, although the QoR-15 (MD: 3.69; 95% CI: 2.60-4.78; P < 0.01; I² = 2.31%) and QoR-40 scores (MD: 5.70; 95% CI: 0.11-11.29; P = 0.046) at 48 h postoperatively demonstrated a statistical improvement, the magnitude of this change did not reach the threshold for clinical relevance. Moreover, ESPB reduced the incidence of PONV (log odds ratio [log(OR)]: -0.63; 95% CI: -1.11--0.14; P = 0.01; I² = 24.62%) and the 24-hour postoperative opioid consumption(SMD: -0.56; 95% CI: -0.83--0.29; P < 0.01; I² = 0%).

CONCLUSION

ESPB was associated with an improvement in the quality of recovery within the first 24 h postoperatively in patients undergoing spinal surgery, along with a reduction in the incidence of PONV and opioid consumption. However, while the improvement in recovery quality at 48 h postoperatively was statistically significant, its clinical significance was limited. These findings suggest that ESPB may be a beneficial adjunct for enhancing postoperative recovery, but further studies are needed to validate its long-term impact and clinical applicability.

摘要

背景

术后恢复质量(QoR)是评估患者术后功能状态恢复和整体生活质量的关键指标。此外,它是评估以患者为中心的麻醉护理效果的重要指标。竖脊肌平面阻滞(ESPB)是一种创新的区域镇痛技术,因其在脊柱手术中的潜在应用而备受关注。尽管一些研究表明ESPB可能改善QoR,但结果仍存在争议且尚无定论。本荟萃分析旨在系统评价ESPB对脊柱手术患者主观恢复质量的影响,目的是提供更有力的证据支持其临床应用。

方法

2024年9月23日,我们在PubMed、Embase、Web of Science、Cochrane图书馆和Scopus数据库中进行了系统检索,以确定与ESPB相关的随机对照试验(RCT)。这些研究评估了ESPB与传统镇痛相比对脊柱手术患者QoR的影响。本研究的主要结局指标是术后24小时的QoR评分,通过经过验证的QoR量表(QoR - 15和QoR - 40)进行评估。次要结局指标包括术后48小时的QoR评分、术后恶心呕吐(PONV)的发生率以及术后24小时内阿片类镇痛药的消耗量。

结果

本荟萃分析纳入了8项研究,共578例患者。结果表明,与对照组相比,ESPB组的整体QoR - 15评分(平均差值[MD]:9.76;95%置信区间[CI]:8.39 - 11.13;P < 0.01;I² = 0%)和QoR - 40评分(MD:11.8;95% CI:6.35 - 17.25;P = 0.000)有所改善,表明具有临床意义的益处。此外,尽管术后48小时的QoR - 15(MD:3.69;95% CI:2.60 - 4.78;P < 0.01;I² = 2.31%)和QoR - 40评分(MD:5.70;95% CI:0.11 - 11.29;P = 0.046)有统计学上的改善,但这种变化的幅度未达到临床相关性阈值。此外,ESPB降低了PONV的发生率(对数比值比[log(OR)]: - 0.63;95% CI: - 1.11 - - 0.14;P = 0.01;I² = 24.62%)以及术后24小时阿片类药物的消耗量(标准化均值差[SMD]: - 0.56;95% CI: - 0.83 - - 0.29;P < 0.01;I² = 0%)。

结论

ESPB与脊柱手术患者术后24小时内恢复质量的改善相关,同时降低了PONV的发生率和阿片类药物的消耗量。然而,虽然术后48小时恢复质量的改善具有统计学意义,但其临床意义有限。这些发现表明ESPB可能是促进术后恢复的有益辅助手段,但需要进一步研究来验证其长期影响和临床适用性。

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