Li Ying, Yang Kai
Department of Science and Education, the Third People's Hospital of Longgang, Clinical Institute of Shantou University Medical College (the Third People's Hospital of Longgang District Shenzhen), Shenzhen, 518100, China.
Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital (the Second Clinical Medical College Jinan University, the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, 518001, China.
BMC Public Health. 2025 Apr 2;25(1):1243. doi: 10.1186/s12889-025-22454-4.
The adverse effect of tobacco smoke exposure on lung function varies among individuals. We aim to investigate whether diet inflammatory potential modifies the association between tobacco smoke exposure and lung function.
This was a cross-sectional study of 11,382 adults from the 2007-2012 National Health and Nutrition Examination Survey. Tobacco smoke exposure was measured using serum cotinine level, and dichotomized as low or high level according to the race/ethnicity-specific cut-points. Forced expiratory volume in 1 s percent of predicted (FEV% predicted), forced vital capacity percent of predicted (FVC% predicted) and FEV/FVC were selected to quantify lung function. Diet inflammatory potential was assessed using dietary inflammatory index (DII), and categorized into quartiles. The modification effect of DII on the relationship between tobacco smoke exposure and lung function were evaluated by multivariate linear regression model with interaction term and stratified analysis.
DII interacted with serum cotinine level in association with FEV% predicted, FVC% predicted and FEV/FVC (P for interaction < 0.05). In individuals with higher DII, serum cotinine level had stronger inverse associations with FEV% predicted, FVC% predicted and FEV/FVC. More specifically, 23 of 28 DII components showed modification effects on the relationship between serum cotinine level and lung function.
Diet inflammatory potential modifies the effect of tobacco smoke exposure on lung function, and tobacco smoke exposure had a stronger adverse impact on lung function among individuals with high diet inflammatory potential, which should attract more attention.
接触烟草烟雾对肺功能的不良影响因人而异。我们旨在研究饮食炎症潜能是否会改变接触烟草烟雾与肺功能之间的关联。
这是一项对2007 - 2012年国家健康与营养检查调查中的11382名成年人进行的横断面研究。使用血清可替宁水平来衡量烟草烟雾暴露情况，并根据种族/族裔特异性切点将其分为低水平或高水平。选择1秒用力呼气容积占预计值百分比（FEV%预计值）、用力肺活量占预计值百分比（FVC%预计值）和FEV/FVC来量化肺功能。使用饮食炎症指数（DII）评估饮食炎症潜能，并将其分为四分位数。通过带有交互项的多元线性回归模型和分层分析来评估DII对烟草烟雾暴露与肺功能之间关系的修饰作用。
DII与血清可替宁水平在与FEV%预计值、FVC%预计值和FEV/FVC的关联中存在交互作用（交互作用P < 0.05）。在DII较高的个体中，血清可替宁水平与FEV%预计值、FVC%预计值和FEV/FVC的负相关更强。更具体地说，28种DII成分中的23种对血清可替宁水平与肺功能之间的关系显示出修饰作用。
饮食炎症潜能改变了接触烟草烟雾对肺功能的影响，并且在饮食炎症潜能高的个体中，接触烟草烟雾对肺功能有更强的不良影响，这应引起更多关注。
