Sarhan Rizk S, Mohammed Raafat R
Department of Internal Medicine, Faculty of Medicine, Benha University, Benha, Egypt.
Hospital Lab, Clinical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Biomedicine (Taipei). 2025 Mar 1;15(1):42-52. doi: 10.37796/2211-8039.1639. eCollection 2025.
Prediabetes precedes Type-2 diabetes development, is characterized by impaired glucose tolerance (IGT) as judged by the 75-g oral glucose tolerance test (75-OGTT) and is associated with higher cardiac risk (CR), dyslipidemia, hepatosteatosis (HS) and cancer.
The study aimed to determine the distinguishing ability of estimated levels of glycated albumin (GA) and hemoglobin A1c (HbA1c), and serum C-reactive protein (CRP) and serum total albumin (TA) levels for prediabetic out of apparently healthy subjects.
IGT was diagnosed if fasting blood glucose (FBG) was 100-125 mg/dl and if < 100 mg/dl subject is normal glucose tolerant (NGT). CR, HS and insulin resistance (IR) were suggested if the calculated atherogenic index of plasma (AIP) was >0.1, HS index (HSI) was >36 with high computerized hepatorenal index (HRI) and the homeostasis model assessment of IR (HOMA-IR) score was >2, respectively.
253 subjects (50.8%) had IGT and were older, more obese and mainly females. IGT had higher GA%, HOMA-IR score, serum CRP and lower TA with high CRP/TA ratio (CAR) than NGT. The frequency of subjects had AIP>0.1, HSI>36 and high HRI was significantly higher among IGT subjects. Statistical analyses defined high GA% and CAR as predictors for IGT, HOMA-IR>36 and AIP score >0.1, while high CAR is the only predictor for HSI score >36 and high HIR score.
Prediabetes is not uncommon and high GA% and CAR might differentiate them among the apparently healthy population, and could predict those at increased risk for IR, HS and at CR.
糖尿病前期先于2型糖尿病出现，其特征为通过75克口服葡萄糖耐量试验（75-OGTT）判断的葡萄糖耐量受损（IGT），并与较高的心脏风险（CR）、血脂异常、肝脂肪变性（HS）和癌症相关。
本研究旨在确定糖化白蛋白（GA）和糖化血红蛋白A1c（HbA1c）的估计水平，以及血清C反应蛋白（CRP）和血清总白蛋白（TA）水平对明显健康受试者中糖尿病前期的鉴别能力。
如果空腹血糖（FBG）为100-125毫克/分升，则诊断为IGT；如果<100毫克/分升，则受试者为正常糖耐量（NGT）。如果计算得出的血浆致动脉粥样硬化指数（AIP）>0.1、HS指数（HSI）>36且伴有高计算机化肝肾指数（HRI）、胰岛素抵抗的稳态模型评估（HOMA-IR）评分>2，则提示存在CR、HS和胰岛素抵抗（IR）。
253名受试者（50.8%）患有IGT，他们年龄更大、更肥胖，且主要为女性。与NGT相比，IGT的GA%、HOMA-IR评分、血清CRP更高，TA更低，且CRP/TA比值（CAR）更高。IGT受试者中AIP>0.1、HSI>36和高HRI的受试者频率显著更高。统计分析确定高GA%和CAR是IGT、HOMA-IR>36和AIP评分>0.1的预测指标，而高CAR是HSI评分>36和高HIR评分的唯一预测指标。
糖尿病前期并不罕见，高GA%和CAR可能在明显健康的人群中对其进行区分，并可预测那些IR、HS和CR风险增加的人群。
