Smith Hunter G, Nimmagadda Sai, Gupta Ruchi S, Warren Christopher M
Department of Pediatrics, Lurie Children's Hospital of Chicago and Northwestern McGaw Pediatrics Residency, Chicago, IL, United States.
Center for Food Allergy and Asthma Research Northwestern Feinberg School of Medicine & Lurie Children's Hospital of Chicago, Chicago, IL, United States.
Front Allergy. 2025 Mar 19;6:1562667. doi: 10.3389/falgy.2025.1562667. eCollection 2025.
The National Institute of Allergy and Infectious Disease (NIAID) addendum guidelines for primary prevention of peanut allergy1 provide recommendations regarding peanut introduction, and a recent consensus statement highlighted the importance of timely introduction of other commonly allergenic solids, and the role of family history as a risk factor.2ObjectiveTo determine whether children in households with a food allergic parent/caregiver or sibling have different rates of being fed commonly allergenic solids during the first year of life than children lacking this family history.
A pretested survey was administered between January-February 2021 to a U.S. sample of 3,062 parents/caregivers of children born since the NIAID Addendum guidelines. Survey-weighted chi-square statistics and logistic regression models tested the independence of key variables across strata of interest before and after covariate adjustment.
Peanut, almond, shellfish, and other tree nuts are more likely to be introduced to children with one or more food-allergic caregivers. Respondents with food-allergic parents (39.3%) and siblings with FA (35.8%) were more familiar with the 2017 NIAID guidelines compared to parents (12.9%) and siblings without FA (12.7%).
Findings suggest that respondents with food-allergic parents and siblings are more likely to have many of the most prevalent allergens introduced at younger ages, which could be due to knowledge related to the NIAID-sponsored guidelines and other national guidance, but that even among these higher-risk families overall rates of "early" introduction during infancy still remain relatively low.
美国国家过敏和传染病研究所(NIAID)关于花生过敏一级预防的增编指南1提供了有关引入花生的建议,最近的一份共识声明强调了及时引入其他常见致敏性固体食物的重要性,以及家族史作为风险因素的作用。2
目的
确定有食物过敏父母/照料者或兄弟姐妹的家庭中的儿童在出生后第一年被喂食常见致敏性固体食物的比例是否与没有这种家族史的儿童不同。
2021年1月至2月间,对自NIAID增编指南发布以来出生的儿童的3062名美国父母/照料者样本进行了预先测试的调查。调查加权卡方统计和逻辑回归模型在协变量调整前后测试了各感兴趣分层中关键变量的独立性。
花生、杏仁、贝类和其他坚果更有可能被引入有一名或多名食物过敏照料者的儿童。与没有食物过敏的父母(12.9%)和兄弟姐妹(12.7%)相比,有食物过敏父母的受访者(39.3%)和有食物过敏的兄弟姐妹(35.8%)对2017年NIAID指南更为熟悉。
研究结果表明,有食物过敏父母和兄弟姐妹的受访者更有可能在儿童较小的时候就引入许多最常见的过敏原,这可能是由于与NIAID赞助的指南和其他国家指南相关的知识,但即使在这些高风险家庭中,婴儿期“早期”引入的总体比例仍然相对较低。