Borges Pamela, Spencer Hirondina Borges, Furtado Stefani, Costa Victor, Barbosa Carla, Santos Lúcio Lara
Molecular Biology Laboratory, Agostinho Neto University Hospital, Praia, Plateau PC-112, Cabo Verde.
Clinical Research and Innovation Center, Agostinho Neto University Hospital, Praia, Plateau PC-112, Cabo Verde.
Ecancermedicalscience. 2025 Jan 16;19:1826. doi: 10.3332/ecancer.2025.1826. eCollection 2025.
Breast cancer is a significant health concern in Cape Verde, but comprehensive data on its presentation, management and outcomes are limited. This study aims to provide insights into breast cancer patterns in this island nation.
We conducted a retrospective analysis of 586 breast cancer patients treated at Agostinho Neto University Hospital in Praia, Cape Verde, from January 2000 to May 2024. Data on demographics, clinical presentation, diagnostic methods, treatment modalities and survival outcomes were collected and analysed.
The study population comprised 578 (98.6%) females and 8 (1.4%) males. The mean age at diagnosis was 52.1 years (SD 13.6) for females and 70 years (SD 16.7) for males. Stage III was the most common presentation (39.4%). Invasive ductal carcinoma was the predominant histological type. Immunohistochemical analysis in 307 patients revealed 69.4% luminal, 26.1% triple-negative and 4.6% HER2-positive subtypes. Treatment primarily involved surgery combined with chemotherapy and/or hormone therapy, with 33.4% receiving radiotherapy. The median follow-up was 36.5 months (range: 1-298 months), and the median survival time was 137.1 months.
This study reveals breast cancer patterns in Cape Verde that share similarities with other African nations, including younger age at diagnosis and higher rates of late-stage presentation compared to Western countries. However, encouraging trends in survival outcomes and diagnostic capabilities were observed. These findings highlight the need for improved early detection strategies and expanded access to comprehensive treatment modalities, particularly radiotherapy, in Cape Verde.
乳腺癌是佛得角一个重大的健康问题，但关于其临床表现、治疗和结局的全面数据有限。本研究旨在深入了解这个岛国的乳腺癌模式。
我们对2000年1月至2024年5月在佛得角普拉亚的阿戈斯蒂纽·内图大学医院接受治疗的586例乳腺癌患者进行了回顾性分析。收集并分析了人口统计学、临床表现、诊断方法、治疗方式和生存结局的数据。
研究人群包括578名（98.6%）女性和8名（1.4%）男性。女性诊断时的平均年龄为52.1岁（标准差13.6），男性为70岁（标准差16.7）。III期是最常见的表现（39.4%）。浸润性导管癌是主要的组织学类型。对307例患者的免疫组化分析显示，管腔型占69.4%，三阴性占26.1%，HER2阳性亚型占4.6%。治疗主要包括手术联合化疗和/或激素治疗，33.4%的患者接受了放疗。中位随访时间为36.5个月（范围：1 - 298个月），中位生存时间为137.1个月。
本研究揭示了佛得角的乳腺癌模式，与其他非洲国家有相似之处，包括与西方国家相比诊断年龄较轻和晚期表现率较高。然而，观察到了生存结局和诊断能力方面令人鼓舞的趋势。这些发现凸显了佛得角需要改进早期检测策略并扩大获得综合治疗方式，特别是放疗的机会。
