Hollmén A I, Eskelinen P, Tolonen U, Arranto J, Sulg I, Jouppila R, Jouppila P
Eur J Anaesthesiol. 1985 Mar;2(1):39-51.
The effects of anaesthetic techniques and drugs on 18 neonates born after elective Caesarean section were studied, employing computerized EEG. Three different groups, epidural, spinal and general anaesthesia, were compared with each other and with a control group after normal vaginal delivery. A new computerized EEG method, Zero Band Power Rate (ZBPR) analysis, was devised for this study and implemented together with conventional spectral EEG estimates of five frequency bands. ZBPR analysis was found to be much more sensitive than conventional spectral analyses for detecting differences between the study groups. Significant differences occurred between the general anaesthesia group and the epidural and control groups and also between the spinal group and the epidural and control groups. No significant difference was seen between the epidural group and the control group. Significant differences were attributed to the clinical use of two drugs: thiopentone in the general anaesthesia group and ephedrine in the spinal group. The effects of these drugs on the neonatal EEG were reflected in decreased ZBPR values, particularly during sleep.
采用计算机化脑电图技术，研究了麻醉技术和药物对18例择期剖宫产出生新生儿的影响。将硬膜外麻醉、脊髓麻醉和全身麻醉三个不同组相互比较，并与正常阴道分娩后的对照组进行比较。本研究设计了一种新的计算机化脑电图方法——零频段功率率（ZBPR）分析，并与传统的五个频段的脑电图频谱估计方法一起实施。结果发现，ZBPR分析在检测研究组之间的差异方面比传统频谱分析更为敏感。全身麻醉组与硬膜外麻醉组及对照组之间以及脊髓麻醉组与硬膜外麻醉组及对照组之间均出现显著差异。硬膜外麻醉组与对照组之间未见显著差异。显著差异归因于两种药物的临床使用：全身麻醉组中的硫喷妥钠和脊髓麻醉组中的麻黄碱。这些药物对新生儿脑电图的影响表现为ZBPR值降低，尤其是在睡眠期间。
