Neumann Elena, Klemm Philipp
Abteilung für Rheumatologie und Klinische Immunologie, Campus Kerckhoff, Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.
Inn Med (Heidelb). 2025 Apr 3. doi: 10.1007/s00108-025-01890-9.
Fibrosis is characterized by an excessive accumulation of extracellular matrix components produced by connective tissue cells. It is a pathophysiological feature of many chronic inflammatory diseases. Nearly every tissue of the body can be affected by fibrosis. Its progression can lead to dysfunction of the affected tissue and organs and potentially death. Early fibrotic mechanisms include the activation of immune responses leading to activation of connective tissue cells and misdirected wound healing responses, finally leading to scarring and fibrosis. Different pathways and factors contribute to the pathophysiology of fibrosis and are summarized in this review.
纤维化的特征是结缔组织细胞产生的细胞外基质成分过度积累。它是许多慢性炎症性疾病的病理生理特征。身体几乎每个组织都可能受到纤维化影响。其进展可导致受影响的组织和器官功能障碍，并可能导致死亡。早期纤维化机制包括免疫反应激活，导致结缔组织细胞激活和伤口愈合反应方向错误，最终导致瘢痕形成和纤维化。不同的途径和因素促成了纤维化的病理生理学，本综述对此进行了总结。
