Kozlowska Justyna, Ciesielska Agnieszka
Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, Toruń, 87-100, Poland.
Institute of Environmental Protection - National Research Institute, Slowicza 32, Warsaw, 02-170, Poland.
Sci Rep. 2025 Apr 3;15(1):11511. doi: 10.1038/s41598-025-95809-x.
This study explores the development and characterization of advanced composite materials combining fish collagen and chitosan, enhanced with chitosan-based microcapsules encapsulating an active ingredient-Calendula officinalis flower extract-hrough ionic gelation using various surfactants (Span 80, Tween 80 and Span80/Tween 80). Collagen was successfully extracted from northern pike scales and integrated with chitosan to create porous, three-dimensional matrices by the lyophilization process. Various amounts of microcapsules were incorporated into the matrices, and the structure of the obtained materials, their mechanical properties, swelling capacity, and susceptibility to degradation were assessed. Matrices with microcapsules exhibited high porosity, substantial swelling capacity, and improved mechanical properties compared to matrices without them. Microcapsules enabled the controlled release of active ingredients, demonstrating potential applications cosmetic industry. This research aligns with current trends in the cosmetics industry, such as the use of sustainable and eco-friendly materials derived from renewable resources like fish waste, the emphasis on natural and bioactive ingredients such as plant extracts, and the development of advanced delivery systems for controlled release of active compounds. The study addresses consumer demand for biodegradable and non-toxic materials, reducing environmental impact while enhancing product efficacy and safety.
本研究探索了结合鱼胶原蛋白和壳聚糖的先进复合材料的开发与特性，这些复合材料通过使用各种表面活性剂（司盘80、吐温80和司盘80/吐温80）的离子凝胶化作用，用包裹活性成分——金盏花花提取物的壳聚糖基微胶囊进行强化。胶原蛋白成功地从白斑狗鱼鳞片中提取出来，并与壳聚糖整合，通过冻干过程制成多孔三维基质。将不同量的微胶囊掺入基质中，并评估所得材料的结构、机械性能、溶胀能力和降解敏感性。与不含微胶囊的基质相比，含微胶囊的基质具有高孔隙率、显著的溶胀能力和改善的机械性能。微胶囊能够实现活性成分的控释，显示出在化妆品行业的潜在应用。本研究符合化妆品行业的当前趋势，例如使用源自鱼类废弃物等可再生资源的可持续和环保材料、强调植物提取物等天然和生物活性成分，以及开发用于活性化合物控释的先进递送系统。该研究满足了消费者对可生物降解和无毒材料的需求，在提高产品功效和安全性的同时减少了对环境的影响。
