Erdõ S, Varga B, Horváth E
Eur J Pharmacol. 1985 May 20;111(3):397-400. doi: 10.1016/0014-2999(85)90650-8.
The effect of gamma-aminobutyric acid (GABA)--superfused onto the surface of the ovary--on ovarian blood flow and on estradiol-17-beta (E2) and progesterone (P) secretion was studied in anaesthesized, pseudopregnant rats. GABA, 0.5 mumol per 50 microliter per animal, significantly reduced the blood pressure in the femoral artery, increased ovarian blood flow, enhanced the rate of E2 release and markedly decreased P secretion. The present findings indicate that local GABAergic mechanisms may be involved in the regulation of ovarian blood flow and hormone secretion.
在麻醉的假孕大鼠中，研究了γ-氨基丁酸（GABA）（超融合到卵巢表面）对卵巢血流以及雌二醇-17-β（E2）和孕酮（P）分泌的影响。每只动物每50微升给予0.5微摩尔GABA，可显著降低股动脉血压，增加卵巢血流，提高E2释放速率，并显著降低P分泌。目前的研究结果表明，局部GABA能机制可能参与卵巢血流和激素分泌的调节。
