饮食氧化平衡评分对糖尿病肾病和肾功能的影响：来自回顾性和横断面研究的见解

Effects of dietary oxidative balance score on diabetic nephropathy and renal function: insights from retrospective and cross-sectional studies.

作者信息

Huang Yong, Wang Linfeng, Zhang Gaojie, Peng Yueqiang, Xu Qiao, Wei Ziling, Yu Jiang, Zhang Huayang, Zhang Yao, Liu Jiayu

机构信息

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Department of Urology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Front Nutr. 2025 Mar 20;12:1560913. doi: 10.3389/fnut.2025.1560913. eCollection 2025.

DOI:10.3389/fnut.2025.1560913

PMID:40181946

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11965115/

Abstract

BACKGROUND

The relationship between dietary oxidative balance score (DOBS) and diabetes-related renal events remains unclear.

METHODS

In this study, the associations between serum micronutrients and diabetic nephropathy (DN) in participants matched by propensity score (PSM) were retrospectively analyzed. And next, a cross-sectional analysis was performed with the National Health and Nutritional Examination Survey (NHANES) database. Weighted multivariate adjusted logistic regression models, dose-response curves, subgroup analysis, and mediation analysis were the main methods of this study. Finally, sensitivity analyses were performed by PSM and multiple imputation (MI).

RESULTS

Retrospective findings suggest that single antioxidants may not be representative of an individual's overall antioxidant levels. The results of the cross-sectional study indicated that the higher the DOBS, the greater the beneficial effects on DN [Q4 vs. Q1: OR (95% CI): 0.78 (0.63, 0.96), for trend = 0.008] and renal function in DN [Q4 vs. Q1: (95% CI): 5.395 (1.590, 9.199), for trend = 0.004]. The above correlations were linear negative correlation ( for nonlinear = 0.989) and linear positive correlation ( for nonlinear = 0.593) respectively. Chronic inflammation mediated the above associations to some extent. The results of sensitivity analysis were consistent with the original analysis.

CONCLUSION

Higher dietary antioxidant exposure has a positive effect on DN and renal function in DN, mediated partially by chronic inflammation.

摘要

背景

饮食氧化平衡评分（DOBS）与糖尿病相关肾脏事件之间的关系尚不清楚。

方法

在本研究中，对倾向评分匹配（PSM）的参与者血清微量营养素与糖尿病肾病（DN）之间的关联进行回顾性分析。接下来，使用美国国家健康与营养检查调查（NHANES）数据库进行横断面分析。加权多变量调整逻辑回归模型、剂量反应曲线、亚组分析和中介分析是本研究的主要方法。最后，通过PSM和多重填补（MI）进行敏感性分析。

结果

回顾性研究结果表明，单一抗氧化剂可能无法代表个体的整体抗氧化水平。横断面研究结果表明，DOBS越高，对DN的有益作用越大[四分位数4（Q4）与四分位数1（Q1）相比：优势比（OR）（95%置信区间）：0.78（0.63，0.96），趋势检验P值=0.008]，对DN患者肾功能的有益作用也越大[Q4与Q1相比：估算肾小球滤过率（eGFR）（95%置信区间）：5.395（1.590，9.199），趋势检验P值=0.004]。上述相关性分别为线性负相关（非线性检验P值=0.989）和线性正相关（非线性检验P值=0.593）。慢性炎症在一定程度上介导了上述关联。敏感性分析结果与原分析一致。