Hao Xuexue, Chen Xiangyu, Ren Congzhe, Pan Yang, Xu Zhunan, Wang Qihua, Liu Xiaoqiang
Department of Urology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
BMC Public Health. 2024 Dec 2;24(1):3362. doi: 10.1186/s12889-024-20880-4.
Individual antioxidants may not fully capture the comprehensive antioxidant intake from an individual's diet. This study utilizes the Complex Dietary Antioxidant Index (CDAI) to evaluate the combined effects of various dietary antioxidants in the diet. The goal is to investigate the relationship between CDAI and the incidence of erectile dysfunction (ED), offering insights for dietary guidelines and intervention strategies aimed at mitigating the burden of ED.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) database in the years 2001-2004. We employed a weighted multivariate logistic regression model to validate the relationship between CDAI and ED. Subgroup analyses were conducted to explore the correlation between CDAI and ED across different subgroups. Additionally, we used propensity score matching (PSM) to adjust for several key confounding variables, enhancing the robustness of the results.
In the fully adjusted multivariate logistic regression model for confounding variables, CDAI is negatively correlated with the risk of ED (OR = 0.95, 95% CI: 0.92-0.99, P = 0.005). When CDAI is transformed into a categorical variable based on quartiles, Q3 (OR = 0.73, 95% CI: 0.53-0.99, P = 0.040) and Q4 (OR = 0.70, 95% CI: 0.51-0.96, P = 0.026) show a negative correlation with the risk of ED. Subgroup analysis reveals no significant interaction. After adjusting for major confounding variables through PSM, the association between CDAI and reduced risk of ED remains significant.
In our study cohort, there is an association between CDAI and a reduced risk of ED, and further research is needed to validate and refine this conclusion.
单一抗氧化剂可能无法完全反映个体饮食中抗氧化剂的综合摄入量。本研究采用复合膳食抗氧化剂指数（CDAI）来评估饮食中各种膳食抗氧化剂的综合作用。目的是探讨CDAI与勃起功能障碍（ED）发病率之间的关系，为旨在减轻ED负担的饮食指南和干预策略提供见解。
这项横断面研究利用了2001 - 2004年美国国家健康与营养检查调查（NHANES）数据库中的数据。我们采用加权多元逻辑回归模型来验证CDAI与ED之间的关系。进行亚组分析以探讨不同亚组中CDAI与ED之间的相关性。此外，我们使用倾向评分匹配（PSM）来调整几个关键的混杂变量，增强结果的稳健性。
在针对混杂变量进行完全调整的多元逻辑回归模型中，CDAI与ED风险呈负相关（OR = 0.95，95% CI：0.92 - 0.99，P = 0.005）。当根据四分位数将CDAI转换为分类变量时，Q3（OR = 0.73，95% CI：0.53 - 0.99，P = 0.040）和Q4（OR = 0.70，95% CI：0.51 - 0.96，P = 0.026）与ED风险呈负相关。亚组分析未发现显著的交互作用。通过PSM调整主要混杂变量后，CDAI与ED风险降低之间的关联仍然显著。
在我们的研究队列中，CDAI与ED风险降低之间存在关联，需要进一步研究来验证和完善这一结论。
