Airaksinen K E, Kirkinen P, Takkunen J T
Eur J Obstet Gynecol Reprod Biol. 1985 May;19(5):269-76. doi: 10.1016/0028-2243(85)90040-1.
We evaluated autonomic nervous function in 14 subjects with severe pre-eclampsia and 11 subjects with normal third-trimester pregnancies using standard cardiovascular tests, i.e. heart rate responses to deep breathing and standing up, and blood pressure response to standing up. Both of the heart rate responses were lower in subjects with severe pre-eclampsia than in the control group (P less than 0.01 and P less than 0.001, respectively). Four subjects with severe pre-eclampsia had postural hypotension, defined as a systolic blood pressure fall of at least 30 mmHg on standing. Our results show that severe pre-eclampsia may be associated with autonomic nervous dysfunction. The inability to regulate heart rate and blood pressure in response to postural alterations may compromise the placental and renal blood flow in certain conditions, emphasising the importance of bed rest in severe pre-eclampsia.
我们使用标准心血管测试，即深呼吸和站立时的心率反应以及站立时的血压反应，对14名重度子痫前期患者和11名孕晚期正常孕妇的自主神经功能进行了评估。重度子痫前期患者的两种心率反应均低于对照组（分别为P<0.01和P<0.001）。4名重度子痫前期患者出现体位性低血压，定义为站立时收缩压至少下降30 mmHg。我们的结果表明，重度子痫前期可能与自主神经功能障碍有关。在某些情况下，无法根据体位改变调节心率和血压可能会损害胎盘和肾脏的血流，这突出了重度子痫前期卧床休息的重要性。
