Ekholm E M, Piha S J, Erkkola R U, Antila K J
Department of Obstetrics and Gynecology, University of Turku, Finland.
Clin Auton Res. 1994 Aug;4(4):161-5. doi: 10.1007/BF01826181.
Cardiovascular reflexes were studied in 22 healthy women before they were pregnant, once during each pregnancy trimester and after delivery to evaluate the effect of pregnancy on autonomic control of haemodynamics. The Valsalva manoeuvre, the deep breathing test, the orthostatic test and the isometric handgrip test were used to assess changes in autonomic nervous function. We found that pregnancy altered the heart rate response in the Valsalva manoeuvre, the deep breathing test and the orthostatic tests. The deep breathing difference (p = 0.03) and max/min ratio (p = 0.03) decreased in pregnancy, whereas standing heart rate increased (p < 0.0001). Both the systolic and diastolic blood pressure increased after standing up during pregnancy. The circulatory responses to isometric exercise were not affected by pregnancy. The results show that parasympathetic responsiveness is decreased in pregnancy and that it returns to normal after delivery.
对22名健康女性在怀孕前、孕期各阶段及产后进行心血管反射研究，以评估妊娠对血液动力学自主控制的影响。采用瓦尔萨尔瓦动作、深呼吸试验、直立试验和等长握力试验来评估自主神经功能的变化。我们发现，妊娠改变了瓦尔萨尔瓦动作、深呼吸试验和直立试验中的心率反应。妊娠期间深呼吸差异（p = 0.03）和最大/最小心率比值（p = 0.03）降低，而立位心率增加（p < 0.0001）。妊娠期间站立后收缩压和舒张压均升高。等长运动的循环反应不受妊娠影响。结果表明，妊娠期间副交感神经反应性降低，产后恢复正常。
