Yılmaz Kaya Zeynep, Kızılırmak Deniz, Havlucu Yavuz
Chest Diseases Department, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.
Support Care Cancer. 2025 Apr 4;33(4):349. doi: 10.1007/s00520-025-09409-6.
Lung cancer is a malignancy marked by low treatment response rates and poor survival outcomes, despite significant advancements in diagnostic and therapeutic approaches. This study aims to examine the impact of dietary habits and physical activity levels on chemotherapy response and survival in patients diagnosed with advanced-stage non-small cell lung cancer.
Patients diagnosed with stage IV non-small cell lung cancer and scheduled to receive platinum-based chemotherapy as the initial treatment were included in the study. Sociodemographic and cancer-related characteristics were documented. At the beginning of treatment, the patients' dietary habits and physical activity levels were evaluated using the "Mediterranean Diet Adherence Scale," the "International Physical Activity Questionnaire," and the "Food Consumption Frequency Form," while their average daily step count was calculated. The study investigated the relationships between dietary habits and physical activity levels with treatment response, 6-month survival, progression-free survival, and chemotherapy-related side effects.
The study included a total of 37 patients, 35 of whom were male, with a mean age of 63.49 years. The 6-month survival rate among these patients was 81.1%. In terms of treatment response, 35.1% of patients experienced disease progression, 54.1% demonstrated partial regression, and 8.1% achieved complete regression. Notably, the 6-month survival rate was significantly higher in minimally physically active patients compared to inactive patients (p = 0.022). Furthermore, patients adhering to the Mediterranean diet exhibited a significantly higher 6-month survival rate compared to those who did not follow the diet (p = 0.019). High adherence to the Mediterranean diet was also associated with a significantly lower incidence of chemotherapy-related gastrointestinal side effects (p < 0.001).
This study demonstrated that physical activity and adherence to the Mediterranean diet positively impact 6-month survival and reduce the incidence of chemotherapy-related side effects.
尽管诊断和治疗方法取得了重大进展，但肺癌仍是一种治疗反应率低、生存结果差的恶性肿瘤。本研究旨在探讨饮食习惯和身体活动水平对晚期非小细胞肺癌患者化疗反应和生存的影响。
本研究纳入了诊断为IV期非小细胞肺癌并计划接受铂类化疗作为初始治疗的患者。记录了社会人口学和癌症相关特征。在治疗开始时，使用“地中海饮食依从性量表”、“国际身体活动问卷”和“食物消费频率表”评估患者的饮食习惯和身体活动水平，同时计算他们的平均每日步数。该研究调查了饮食习惯和身体活动水平与治疗反应、6个月生存率、无进展生存期和化疗相关副作用之间的关系。
该研究共纳入37例患者，其中35例为男性，平均年龄63.49岁。这些患者的6个月生存率为81.1%。在治疗反应方面，35.1%的患者病情进展，54.1%的患者部分缓解，8.1%的患者完全缓解。值得注意的是，与不活动的患者相比，身体活动最少的患者6个月生存率显著更高（p = 0.022）。此外，坚持地中海饮食的患者6个月生存率显著高于不遵循该饮食的患者（p = 0.019）。高度坚持地中海饮食还与化疗相关胃肠道副作用的发生率显著降低相关（p < 0.001）。
本研究表明，身体活动和坚持地中海饮食对6个月生存率有积极影响，并降低化疗相关副作用的发生率。
