推进上消化道癌症检测：一项探索电阻抗光谱在内镜检查中潜力的单中心试点研究。
Advancing Upper Gastrointestinal Cancer Detection: A Single-Center Pilot Study Exploring the Potential of Electrical Impedance Spectroscopy in Endoscopic Procedures.
作者信息
Dowlatabad Hadi Mokhtari, Mahdavi Reihane, Miri Seyed Rouhollah, Fattahi Mohammad Reza, Ataee Hossein, Yousefpour Narges, Manoochehri Navid, Taslimi Reza, Abdolahad Mohammad
机构信息
Nano Bioelectronics Devices Lab (NBEL), Cancer Electronics Research Group, School of Electrical and Computer Engineering, Faculty of Engineering, University of Tehran, P.O. Box, Tehran, 14399-57131, Iran.
UT&TUMS Cancer Electronics Research Center, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.
出版信息
Dig Dis Sci. 2025 Apr 5. doi: 10.1007/s10620-025-08983-3.
PURPOSE
Early detection of GI cancer mass is of utmost importance due to the risks of misdiagnoses that occur through standard endoscopic evaluation.
METHODS
In this research, a real-time intra-endoscopic electrical diagnostic probe has been introduced to discriminate high-risk excision-required lesions utilizing a modified endoscopic biopsy forceps as a non-invasive method.
RESULTS
By testing on 52 patients who had undergone endoscopic biopsy with a total of 18 high-risk lesions, the invented device named Electrical Endoscopic Mass Characterizer (EEMC), showed %94.7 sensitivity, %93.9 specificity, and %94.2 accuracy (p < 0.01) based on histopathological evaluations of removed specimens as the gold standard.
CONCLUSIONS
EEMC can be utilized as a precise complementary device during endoscopic evaluation for improving the accuracy of early-stage GI cancer detection with no interruptions in the routine procedure.
目的
由于标准内镜评估存在误诊风险，早期发现胃肠道（GI）癌肿块至关重要。
方法
在本研究中，引入了一种实时内镜电诊断探头，以利用改良的内镜活检钳作为非侵入性方法来鉴别需要切除的高风险病变。
结果
通过对52例接受内镜活检的患者进行测试，共有18个高风险病变，以切除标本的组织病理学评估作为金标准，名为内镜电肿块特征仪（EEMC）的发明装置显示出94.7%的灵敏度、93.9%的特异性和94.2%的准确率（p < 0.01）。
结论
EEMC可在内镜评估期间用作精确的辅助设备，以提高早期胃肠道癌检测的准确性，且不干扰常规程序。
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