Takagi T, Tanizawa O, Otsuki Y, Sugita N, Haruta M, Yamaji K
Horm Metab Res. 1985 Jun;17(6):308-10. doi: 10.1055/s-2007-1013526.
The oxytocin concentration in the cerebrospinal fluid (CSF) and plasma of pregnant women at term with and without labor pain were measured by radioimmunoassay and compared with those of non-pregnant women of matched age. The oxytocin concentrations in the CSF were 4.9 +/- 4.1 microU/ml (mean +/- S.D.) in pregnant women with labor pain, 4.1 +/- 2.4 microU/ml in those without labor pain and 4.0 +/- 2.8 microU/ml in nonpregnant women, and the oxytocin concentrations in the plasma of these subjects were 45.2 +/- 19.6, 17.1 +/- 22.2 and 7.0 +/- 5.3 microU/ml, respectively. Thus the oxytocin level in the CSF did not change appreciably even when the level in the plasma was raised in the pregnant women with labor pain. These findings suggest that oxytocin does not penetrate the blood-brain barrier, and that oxytocin in the CFS has little or no central role in parturition in women.
采用放射免疫分析法测定了足月有或无分娩疼痛的孕妇脑脊液（CSF）和血浆中的催产素浓度，并与年龄匹配的未孕女性进行比较。有分娩疼痛的孕妇脑脊液中催产素浓度为4.9±4.1微单位/毫升（均值±标准差），无分娩疼痛的孕妇为4.1±2.4微单位/毫升，未孕女性为4.0±2.8微单位/毫升，这些受试者血浆中的催产素浓度分别为45.2±19.6、17.1±22.2和7.0±5.3微单位/毫升。因此，即使有分娩疼痛的孕妇血浆中催产素水平升高，其脑脊液中的催产素水平也没有明显变化。这些发现表明，催产素不能穿透血脑屏障，并且脑脊液中的催产素在女性分娩过程中几乎没有或根本没有中枢作用。
