Takeda S, Kuwabara Y, Mizuno M
Endocrinol Jpn. 1985 Dec;32(6):875-80. doi: 10.1507/endocrj1954.32.875.
In order to investigate the significance of oxytocin in pregnancy and labor, oxytocin concentrations in plasma and cerebrospinal fluid (CSF) were determined using the specific radioimmunoassay. Plasma and CSF samples were obtained from 23 pregnant women (11 pre labor, 12 in labor), 15 nonpregnant women and 4 men at spinal puncture for anesthesia. In males and nongravidas, CSF levels of oxytocin were significantly higher than plasma levels. Plasma levels in pregnant patients pre or in labor were significantly higher than those in nongravidas. No significant difference between CSF levels in prelabor gravidas (mean +/- SE, 9.7 +/- 1.5 mu u/ml) and nongravidas (10.1 +/- 1.2 mu u/ml) was found. However, CSF levels in gravidas in labor (18.6 +/- 2.3 micromicrons/ml were significantly higher than the levels in prelabor gravidas. These results strongly suggest that oxytocin levels in human plasma and CSF are controlled by different mechanisms and that the increased oxytocin could have some specific central actions.
为了研究催产素在妊娠和分娩中的意义，采用特异性放射免疫分析法测定了血浆和脑脊液（CSF）中的催产素浓度。血浆和脑脊液样本取自23名孕妇（11名临产前、12名分娩时）、15名非孕妇以及4名因麻醉而行腰椎穿刺的男性。在男性和非孕妇中，脑脊液中的催产素水平显著高于血浆水平。临产前或分娩时孕妇的血浆水平显著高于非孕妇。未发现临产前孕妇（均值±标准误，9.7±1.5微微单位/毫升）和非孕妇（10.1±1.2微微单位/毫升）的脑脊液水平有显著差异。然而，分娩时孕妇的脑脊液水平（18.6±2.3微微单位/毫升）显著高于临产前孕妇。这些结果有力地表明，人血浆和脑脊液中的催产素水平受不同机制控制，且催产素水平升高可能具有某些特定的中枢作用。
