Horowitz M, Need A G, Philcox J C, Nordin B E
Horm Metab Res. 1985 Jun;17(6):311-2. doi: 10.1055/s-2007-1013527.
Although calcium supplements are widely used in the treatment of osteoporosis, their beneficial effect is not conclusively established. We now report some effects of a calcium supplement (1 g/day) given for 6 to 12 weeks to 15 postmenopausal osteoporotic women. The mean fasting urinary hydroxyproline/creatinine ratio decreased from 0.021 +/- 0.002 to 0.015 +/- 0.001 (P less than 0.0025), indicating a significant reduction in bone resorption. The mean plasma alkaline phosphatase fell from 123 +/- 5 U/l to 104 +/- 3.1 U/l (P less than 0.01), probably representing some secondary reduction in bone formation following the inhibition of bone resorption. These results support the concept that calcium supplementation is useful in the treatment of postmenopausal osteoporosis.
尽管钙补充剂被广泛用于治疗骨质疏松症，但其有益效果尚未得到确凿证实。我们现在报告对15名绝经后骨质疏松症女性给予钙补充剂（每日1克），持续6至12周后的一些效果。空腹尿羟脯氨酸/肌酐平均比值从0.021±0.002降至0.015±0.001（P<0.0025），表明骨吸收显著减少。血浆碱性磷酸酶平均值从123±5 U/L降至104±3.1 U/L（P<0.01），这可能代表在骨吸收受到抑制后骨形成出现了一些继发性减少。这些结果支持了钙补充剂对治疗绝经后骨质疏松症有用的观点。
