Abdalla H I, Hart D M, Lindsay R, Leggate I, Hooke A
Obstet Gynecol. 1985 Dec;66(6):789-92.
The effect of norethisterone on bone mineral metabolism was examined in 43 postmenopausal women. A significant decline in serum calcium, phosphate, and alkaline phosphatase in urinary calcium/creatinine ratio and in tubular maximum reabsorption of phosphate was demonstrated. There was no alteration in urinary hydroxyproline/creatinine ratio. The bone mineral content measured over two years by single photon absorptiometry was compared in 20 patients receiving norethisterone and a matched control group receiving placebo. There was significant protection against bone loss in the norethisterone group.
对43名绝经后女性研究了炔诺酮对骨矿物质代谢的影响。结果显示血清钙、磷酸盐、尿钙/肌酐比值中的碱性磷酸酶以及磷酸盐肾小管最大重吸收率均显著下降。尿羟脯氨酸/肌酐比值无变化。通过单光子吸收法对20名接受炔诺酮治疗的患者和接受安慰剂的匹配对照组在两年内测量的骨矿物质含量进行了比较。炔诺酮组对骨质流失有显著的保护作用。
