Pituch-Noworolska A, Noworolski J, Pryjma J, Zembala M
Immunology. 1985 Aug;55(4):693-701.
Supernatants from 18-hr cultures of human peripheral blood polymorphonuclear cells (PMN) and adherent cells (AC) inhibited the binding of erythrocyte-antibody complexes (EA) by PMN. The inhibitory activity was lost upon absorption on IgG and Fc, but not on the F(ab')2 fragment of IgG. IgG-binding material (shed Fc receptor--FcR) was reutilized by PMN and AC which had lost their own FcR in vitro. Reutilization was independent of the type of cells from which FcR originated. The FcR-containing material eluted from IgG-coated Sepharose column inhibited PHA-induced lymphoproliferation, probably via prior interaction with monocytes. These results suggest that shed FcR may be freely exchanged between different types of human leucocytes and play a role in the suppression of mitogen-induced T-cell responses.
人外周血多形核细胞（PMN）和贴壁细胞（AC）18小时培养物的上清液可抑制PMN对红细胞-抗体复合物（EA）的结合。该抑制活性在IgG和Fc上吸附后丧失，但在IgG的F(ab')2片段上吸附后不丧失。IgG结合物质（脱落的Fc受体-FcR）可被PMN和AC重新利用，这些细胞在体外已失去自身的FcR。重新利用与FcR来源的细胞类型无关。从IgG包被的琼脂糖柱上洗脱的含FcR物质可抑制PHA诱导的淋巴细胞增殖，可能是通过与单核细胞的预先相互作用。这些结果表明，脱落的FcR可能在不同类型的人类白细胞之间自由交换，并在抑制丝裂原诱导的T细胞反应中发挥作用。
