胃癌患者体内“活化”的单核细胞。I. 增强的Fc受体表达、抗体依赖性细胞毒性及NBT还原反应
"Activated" monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction.
作者信息
Uracz W, Pituch-Noworolska A, Zembala M, Popiela T, Czupryna A
出版信息
J Cancer Res Clin Oncol. 1982;104(1-2):181-90. doi: 10.1007/BF00402066.
The Fc receptor expression, antibody-dependent cellular cytotoxicity (ADCC), and nitro-blue tetrazolium (NBT) reduction of peripheral blood monocytes from 150 patients with different stages of gastric cancer was assessed and compared with results obtained in 77 normal persons and 104 patients with non-malignant diseases of the gut. Monocytes of cancer patients showed an increased ability to form rosettes with human 0, Rh + erythrocytes coated with D-specific antibody. ADCC and NBT reduction were also elevated but no correlation was found with the stage of disease. However, all these phenomena were related to the tumor load as elevated values were the same 4-6 months after surgery in the unresectable-tumor group, while they decreased in patients with resectable tumors. These observations suggest that monocytes of some cancer patients are functionally altered ("activated") in the course of disease.
评估了150例不同阶段胃癌患者外周血单核细胞的Fc受体表达、抗体依赖性细胞毒性（ADCC）以及硝基蓝四氮唑（NBT）还原情况，并与77名正常人和104例肠道非恶性疾病患者的结果进行了比较。癌症患者的单核细胞与包被有D特异性抗体的人O型、Rh+红细胞形成玫瑰花结的能力增强。ADCC和NBT还原也升高，但与疾病分期无关。然而，所有这些现象都与肿瘤负荷有关，因为不可切除肿瘤组术后4 - 6个月这些升高的值相同，而可切除肿瘤患者的值则下降。这些观察结果表明，一些癌症患者的单核细胞在疾病过程中功能发生了改变（“活化”）。
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