Fujita K, Fujita H M
Int J Clin Pharmacol Ther Toxicol. 1985 Jun;23(6):291-4.
Large organelles, namely mitochondria and lysosomes, were fractionated from rat kidney. Antibiotics were added to the fraction and recombinated with no antibiotic-containing supernatant fraction. Tetracycline was quickly dissolved from the large organelle fraction. Cephaloridine had more affinity to organelles than tetracycline. Binding of amikacin was strongest and partly irreversible when added in vivo.
从大鼠肾脏中分离出大型细胞器，即线粒体和溶酶体。将抗生素添加到该组分中，并与不含抗生素的上清液组分重新组合。四环素迅速从大型细胞器组分中溶解出来。头孢噻啶对细胞器的亲和力比四环素更强。阿米卡星在体内添加时的结合力最强且部分不可逆。
