Fujita K
Hinyokika Kiyo. 1984 Jul;30(7):953-6.
A two-compartment model of kidney cells is designed. The first compartment is the cytoplasm, the other is a large organelle fraction consisting of lysosomes and mitochondria. Drugs easily accumulated in the second compartment are considered to be harmful to the kidney. Although small molecular antibiotics move across membranes, they reach a certain equilibrium within 30 minutes. Therefore reproducible values of antibiotic concentrations in both fractions can be obtained. The two-compartment model provides a new approach to pharmacokinetic study at a subcellular level.
设计了一种肾细胞的双室模型。第一个室是细胞质，另一个是由溶酶体和线粒体组成的大细胞器部分。容易在第二个室中积累的药物被认为对肾脏有害。尽管小分子抗生素可跨膜移动，但它们在30分钟内达到一定的平衡。因此，可以获得两个部分中抗生素浓度的可重复值。该双室模型为亚细胞水平的药代动力学研究提供了一种新方法。
