Aziz Nouman, Nabi Waseem, Khan Muzamil, Gulzar Abu Huraira Bin, Rath Shree, Cheema Asad Ali Ahmed, Arshad Mirza Ammar, Hussain Fatima, Titus Abraham, Lal Amar, Anwar Faiz
Wyckoff Heights Medical Center Program, Brooklyn, NY.
Department of Internal Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC.
Clin Lymphoma Myeloma Leuk. 2025 Aug;25(8):e553-e562. doi: 10.1016/j.clml.2025.03.006. Epub 2025 Mar 13.
Leukemia is a hematologic malignancy with varying incidence and outcomes influenced by demographic and geographic factors. Understanding mortality trends and disparities is essential for guiding public health policy.
To analyze leukemia mortality trends in the U.S. from 1999 to 2020, focusing on age-adjusted mortality rates (AAMRs), disparities, and geographic patterns.
Data from the CDC WONDER database were analyzed, covering leukemia-related deaths (ICD-10 codes C91-C95). Age groups were stratified into < 45 and ≥ 45 years. Joinpoint regression models estimated annual percentage changes (APCs). Data were examined by demographics, census regions, and urbanization levels.
AAMRs for individuals ≥ 45 years declined by an APC of -0.90% but increased slightly from 2018 to 2020. Males, non-Hispanic Whites, and rural populations exhibited higher AAMRs. Among individuals < 45 years old, AAMRs consistently declined with minimal disparities. Acute myeloid leukemia was predominant among older adults, while acute lymphoblastic leukemia affected younger populations.
Despite overall declines in leukemia mortality, persistent disparities across age, gender, and geographic regions highlight inequities in healthcare access. Strategic interventions are required to address these gaps and enhance leukemia care nationwide.
白血病是一种血液系统恶性肿瘤，其发病率和预后因人口统计学和地理因素而异。了解死亡率趋势和差异对于指导公共卫生政策至关重要。
分析1999年至2020年美国白血病死亡率趋势，重点关注年龄调整死亡率（AAMRs）、差异和地理模式。
分析了疾病控制与预防中心（CDC）的WONDER数据库中的数据，涵盖与白血病相关的死亡（国际疾病分类第十版代码C91 - C95）。年龄组分为<45岁和≥45岁。Joinpoint回归模型估计年度百分比变化（APC）。数据按人口统计学、人口普查区域和城市化水平进行检查。
≥45岁个体的年龄调整死亡率以-0.90%的年度百分比变化下降，但在2018年至2020年略有上升。男性、非西班牙裔白人及农村人口的年龄调整死亡率较高。在<45岁的个体中，年龄调整死亡率持续下降，差异最小。急性髓系白血病在老年人中占主导，而急性淋巴细胞白血病影响较年轻人群。
尽管白血病死亡率总体下降，但年龄、性别和地理区域之间持续存在的差异凸显了医疗保健可及性方面的不公平。需要采取战略干预措施来弥补这些差距并加强全国范围内的白血病护理。
