Lu Rui-Ling, Huang Qin, Yu Tian-Tian, Liu Dong-Zhou, Hong Xiao-Ping
Department of Rheumatology and Immunology, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong, China.
Department of Rheumatology and Immunology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
BMC Cardiovasc Disord. 2025 Apr 7;25(1):262. doi: 10.1186/s12872-025-04702-y.
The burden of interstitial lung disease (ILD)-associated heart failure (HF) poses a significant challenge to the prognosis of ILD patients. This study aimed to characterize the disease burden and analyse future trends of ILD-associated HF, offering valuable insights to inform targeted prevention and control strategies.
Data on the prevalence and years lived with disability (YLDs) of ILD-associated HF were retrieved from the Global Burden of Disease (GBD) database for the period 1990-2021. Trends in ILD-associated HF were evaluated using average annual percentage change (AAPC) and percentage change analyses. Future prevalence data were projected up to 2050 using predictive modelling.
Globally, the number of patients with ILD-associated HF increased from 20,229 in 1990 to 104,059 in 2021, with the prevalence rising from 0.53 to 1.41 per 100,000 population. Prevalence rates were disproportionately higher in older populations, with individuals over 95 years experiencing a 17.78-fold increase over the study period. Additionally, a positive correlation was observed between higher socioeconomic development index (SDI) levels and ILD-associated HF prevalence. Among 204 countries, 71.1% exhibited an increasing trend in prevalence. However, Bayesian age-period-cohort (BAPC) modelling predicts a declining trend over the next 28 years.
Over the past three decades, the global burden of ILD-associated HF has escalated, particularly among individuals aged over 65 and in regions with high SDI levels. These findings underscore the need for region-specific, personalized intervention strategies to mitigate disease progression and enhance the quality of life for ILD patients.
间质性肺疾病（ILD）相关心力衰竭（HF）的负担对ILD患者的预后构成了重大挑战。本研究旨在描述ILD相关HF的疾病负担并分析其未来趋势，为制定有针对性的预防和控制策略提供有价值的见解。
从全球疾病负担（GBD）数据库中检索1990 - 2021年期间ILD相关HF的患病率和伤残调整生命年（YLDs）数据。使用年均百分比变化（AAPC）和百分比变化分析评估ILD相关HF的趋势。通过预测模型预测到2050年的未来患病率数据。
在全球范围内，ILD相关HF患者数量从1990年的20229例增加到2021年的104059例，患病率从每10万人0.53例上升至1.41例。老年人群的患病率过高，95岁以上个体在研究期间患病率增加了17.78倍。此外，较高的社会经济发展指数（SDI）水平与ILD相关HF患病率之间存在正相关。在204个国家中，71.1%的国家患病率呈上升趋势。然而，贝叶斯年龄-时期-队列（BAPC）模型预测在未来28年内患病率呈下降趋势。
在过去三十年中，全球ILD相关HF的负担不断升级，尤其是在65岁以上人群和高SDI水平地区。这些发现强调需要采取针对特定区域的个性化干预策略，以减缓疾病进展并提高ILD患者的生活质量。
