Yi Qi-Qi, Sun Ping, Zhang Xinyi, Wang Hao, Wu Jian
State Key Laboratory of Green Pesticide, Guizhou University, Huaxi District, Guiyang 550025, China.
J Agric Food Chem. 2025 Apr 16;73(15):8756-8774. doi: 10.1021/acs.jafc.5c00430. Epub 2025 Apr 7.
Thiourea, represented by the chemical formula (RRN)(RRN)C═S, is a significant organic sulfur compound characterized by the presence of a sulfur atom and two amino groups. Meanwhile, thiourea and isothiourea are reciprocal isomers. This structure facilitates the formation of a biologically active moiety, which is interconnected through double bonds between the sulfur atom and the nitrogen atoms. As a potent component in pesticide formulations, thiourea demonstrates efficacy in safeguarding crops against a variety of diseases by inhibiting the growth and reproduction of pathogens. This review aims to provide a comprehensive summary of thiourea derivatives exhibiting fungicidal, insecticidal, antiviral, herbicidal, and plant growth regulatory properties, with the objective of offering new perspectives for identifying innovative thiourea-based pesticides and elucidating their mechanisms of action.
硫脲的化学式为(RRN)(RRN)C═S，是一种重要的有机硫化合物，其特征是含有一个硫原子和两个氨基。同时，硫脲和异硫脲是互变异构体。这种结构有利于形成一个生物活性部分，该部分通过硫原子和氮原子之间的双键相互连接。作为农药制剂中的一种有效成分，硫脲通过抑制病原体的生长和繁殖，在保护作物免受多种病害方面显示出功效。本综述旨在全面总结具有杀菌、杀虫、抗病毒、除草和植物生长调节特性的硫脲衍生物，以期为鉴定新型硫脲基农药及其作用机制提供新的视角。
