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农药靶标结构研究进展

Review on Structures of Pesticide Targets.

机构信息

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.

College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China.

出版信息

Int J Mol Sci. 2020 Sep 28;21(19):7144. doi: 10.3390/ijms21197144.

Abstract

Molecular targets play important roles in agrochemical discovery. Numerous pesticides target the key proteins in pathogens, insect, or plants. Investigating ligand-binding pockets and/or active sites in the proteins' structures is usually the first step in designing new green pesticides. Thus, molecular target structures are extremely important for the discovery and development of such pesticides. In this manuscript, we present a review of the molecular target structures, including those of antiviral, fungicidal, bactericidal, insecticidal, herbicidal, and plant growth-regulator targets, currently used in agrochemical research. The data will be helpful in pesticide design and the discovery of new green pesticides.

摘要

分子靶标在农用化学品的发现中起着重要作用。许多农药的作用靶标是病原体、昆虫或植物中的关键蛋白。在设计新的绿色农药时,通常首先要研究蛋白质结构中的配体结合口袋和/或活性位点。因此,分子靶标结构对于此类农药的发现和开发至关重要。在本文中,我们综述了农用化学品研究中当前使用的抗病毒、杀菌、杀虫、除草和植物生长调节剂等分子靶标结构。这些数据将有助于农药设计和新的绿色农药的发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ed4/7582455/b0d112513b56/ijms-21-07144-g001.jpg

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