Amiryaghoubi Nazanin, Jahanban Esfahlan Rana
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Adv Pharm Bull. 2024 Dec 30;14(4):794-806. doi: 10.34172/apb.43818. Epub 2024 Oct 16.
Bone organ is comprised of an organic and inorganic environment, in which the collagen element and the mineral part are structured into spongy constructions. Hydroxyapatite (HAp) is the chief inorganic constituent of human bone. HAp is extensively utilized in bone tissue regeneration for its biocompatibility and a rising number of investigators are discovering ways to recover the physical belongings and biological roles of HAp. However, this biomimetic material indicates poor mechanical strength, for example, low tensile and compressive strength, which offer it inappropriate for bone tissue engineering. For this point, HAp is frequently utilized in a mixture with diverse polymers to increase their mechanical strengths and the general function of the implantable biomaterials advanced for orthopedic usage. In this review, we attempt to contribute a brief and inclusive outline of HAp-based natural and synthetic polymer materials to strengthen structures and their applications in bone tissue regeneration.
骨器官由有机和无机环境组成，其中胶原成分和矿物质部分构成海绵状结构。羟基磷灰石（HAp）是人体骨骼的主要无机成分。由于其生物相容性，HAp被广泛应用于骨组织再生，并且越来越多的研究人员正在探索恢复HAp物理性质和生物学作用的方法。然而，这种仿生材料的机械强度较差，例如拉伸强度和抗压强度较低，这使其不适用于骨组织工程。为此，HAp经常与各种聚合物混合使用，以提高其机械强度以及用于骨科的可植入生物材料的整体性能。在本综述中，我们试图简要全面地概述基于HAp的天然和合成聚合物材料以增强结构及其在骨组织再生中的应用。
