Colloca Luana, Han Anna, Massalee Rachel, Raghuraman Nandini, Cundiff-O'Sullivan Rachel L, Colloca Giancarlo, Wang Yang
Department of Pain Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, USA.
NPJ Digit Med. 2025 Apr 7;8(1):192. doi: 10.1038/s41746-025-01553-x.
The efficacy of telehealth Virtual Reality (VR) for chronic pain, a promising digital intervention, remains underexplored due to methodological challenges. In a 5-week crossover trial, we compared VR to matched audio content control in individuals with chronic pain. VR significantly reduced pain intensity, anxiety, and pain interference while improving mood and sleep quality. Findings highlight the potential of telehealth-based VR for addressing real-world challenges in managing chronic pain. ISRCTN12473220 (07/18/2023).
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