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一项关于慢性疼痛患者使用大麻二酚(CBD)分离物、其感知益处及相关副作用的调查。

A Survey on the Use of Cannabidiol (CBD) Isolate, Its Perceived Benefits, and Associated Side Effects Among Subjects With Chronic Pain.

作者信息

Huang Austin, Stolzenberg Laurence, Usman Mohammad, Awan Muhammad, Bruner Paul, MacGregor Gordon

机构信息

Neurology, Alabama College of Osteopathic Medicine, Dothan, USA.

Radiology, Firelands Regional Medical Center, Sandusky, USA.

出版信息

Cureus. 2025 Mar 7;17(3):e80198. doi: 10.7759/cureus.80198. eCollection 2025 Mar.

Abstract

INTRODUCTION

Chronic pain is a pervasive health issue in the United States, affecting up to 50 million adults and contributing to a substantial economic burden. The worsening opioid crisis has increased the need for nonopiate, nonaddictive alternatives to pain management. Cannabidiol (CBD) has recently garnered attention for its potential analgesic and anti-inflammatory properties without addictive or dependence potential. However, there is limited research regarding the efficacy and safety of CBD in the treatment of chronic pain. This study aimed to explore the use of CBD isolate in adults suffering from chronic pain.

METHODS

We decided to investigate its perceived effectiveness, dosage, frequency of use, and reported side effects through a publicly available, completely anonymous Qualtrics survey. This survey was posted online and in multiple medical clinics.

RESULTS

The key findings of our anonymous online survey are that the use of cannabinoids is positively associated with decreased chronic pain, even at low dosages (<100 mg). In addition, though some mild side effects are noted, the majority of patients self-report no side effects, and there are no noted severe side effects.

CONCLUSION

These findings suggest that CBD may serve as a promising alternative to conventional pain management strategies. However, the results warrant further investigation and research into the efficacy and safety of CBD for chronic pain. We believe these data point the way for new and continued avenues of research that can better optimize treatment regimens and help patients with chronic pain.

摘要

引言

慢性疼痛是美国普遍存在的健康问题,影响多达5000万成年人,并造成巨大的经济负担。日益严重的阿片类药物危机增加了对非阿片类、无成瘾性疼痛管理替代方案的需求。大麻二酚(CBD)最近因其潜在的镇痛和抗炎特性而受到关注,且无成瘾或依赖潜力。然而,关于CBD治疗慢性疼痛的疗效和安全性的研究有限。本研究旨在探讨CBD分离物在慢性疼痛成人患者中的应用。

方法

我们决定通过公开可用的、完全匿名的Qualtrics调查来研究其感知效果、剂量、使用频率和报告的副作用。该调查发布在网上和多家医疗诊所。

结果

我们匿名在线调查的主要发现是,即使在低剂量(<100毫克)下,使用大麻素也与慢性疼痛减轻呈正相关。此外,尽管注意到一些轻微副作用,但大多数患者自我报告无副作用,且未发现严重副作用。

结论

这些发现表明,CBD可能是传统疼痛管理策略的一个有前景的替代方案。然而,结果需要对CBD治疗慢性疼痛的疗效和安全性进行进一步调查和研究。我们相信这些数据为新的和持续的研究途径指明了方向,这些研究可以更好地优化治疗方案并帮助慢性疼痛患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf18/11973414/159f77a9b22e/cureus-0017-00000080198-i01.jpg

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