Lee Jeong-A, Han Yoon Kyung, Jung Won Je, Lee Byung H, Lee Seunghoon
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
Department of Nursing, Samsung Medical Center, Seoul, Korea.
J Headache Pain. 2025 Apr 7;26(1):68. doi: 10.1186/s10194-025-02010-6.
Pain is influenced by many factors such as personality traits and nociceptive stimuli. This study identified personality traits in patients with trigeminal neuralgia (TN) and investigated the relationships between personality traits and pain perception, pain acceptance, anxiety, and depression.
From March to June 2024, the personality traits of 50 patients with TN and 50 healthy controls (HC) were measured using the 50-item International Personality Item Pool representation of Goldberg markers for the Big-Five factor structure. Patients' pain perception, pain acceptance, anxiety, and depression were measured.
The mean neuroticism scores and median anxiety and depression scores of patients with TN were higher than those of HC (p = 0.006, p < 0.001, and p = 0.010). There were no significant differences in pain perception and pain acceptance according to the personality traits. The higher the neuroticism score, the higher the anxiety and depression scores (ρ = 0.437, p = 0.002 and ρ = 0.344, p = 0.014). The higher the anxiety score, the higher the pain catastrophizing score, and the lower the pain acceptance score (ρ = 0.488, p < 0.001 and ρ = -0.365, p = 0.009). Higher depression score was associated with a pain frequency of 11 or more times per 24 h (odds ratio = 1.243, p = 0.015). The higher the depression score, the lower was the pain acceptance score (ρ = -0.324, p = 0.022).
In patients with TN, neuroticism was not associated with pain. However, higher levels of neuroticism were associated with higher levels of anxiety and depression, and higher levels of anxiety and depression were associated with higher pain catastrophizing or pain frequency, and lower pain acceptance. These results can be used to establish individualized treatments for patients with TN, that focus on their emotional states according to personality traits, such as adapting psychological therapies differently for individuals with high neuroticism.
疼痛受多种因素影响，如人格特质和伤害性刺激。本研究确定了三叉神经痛（TN）患者的人格特质，并调查了人格特质与疼痛感知、疼痛接受度、焦虑和抑郁之间的关系。
2024年3月至6月，使用戈德堡大五因素结构标记的50项国际人格项目池量表测量了50例TN患者和50例健康对照者（HC）的人格特质。测量了患者的疼痛感知、疼痛接受度、焦虑和抑郁情况。
TN患者的神经质平均分以及焦虑和抑郁中位数得分高于HC（p = 0.006，p < 0.001，p = 0.010）。根据人格特质，疼痛感知和疼痛接受度无显著差异。神经质得分越高，焦虑和抑郁得分越高（ρ = 0.437，p = 0.002；ρ = 0.344，p = 0.014）。焦虑得分越高，疼痛灾难化得分越高，疼痛接受度得分越低（ρ = 0.488，p < 0.001；ρ = -0.365，p = 0.009）。抑郁得分越高与每24小时疼痛发作11次或更多次相关（优势比 = 1.243，p = 0.015）。抑郁得分越高，疼痛接受度得分越低（ρ = -0.324，p = 0.022）。
在TN患者中，神经质与疼痛无关。然而，较高水平的神经质与较高水平的焦虑和抑郁相关，较高水平的焦虑和抑郁与较高的疼痛灾难化或疼痛发作频率以及较低的疼痛接受度相关。这些结果可用于为TN患者制定个体化治疗方案，即根据人格特质关注其情绪状态，如对高神经质个体采用不同的心理治疗方法。
