气单胞菌属的侵袭性与生物型、毒力因子及临床特征的关系
Invasiveness of Aeromonas spp. in relation to biotype, virulence factors, and clinical features.
作者信息
Watson I M, Robinson J O, Burke V, Gracey M
出版信息
J Clin Microbiol. 1985 Jul;22(1):48-51. doi: 10.1128/jcm.22.1.48-51.1985.
Of 69 fecal isolates of Aeromonas spp., 18 had the ability to invade HEp-2 cells. Invasiveness correlated with biotype; of the 18 invasive strains, 16 were A. sobria and 2 were A. hydrophila. No invasive strains were found among the A. caviae. Of the 18 invasive strains, 13 were enterotoxigenic. Of the enterotoxigenic and invasive strains, 12 were A. sobria, but enterotoxicity was also more common among noninvasive strains of A. sobria. Fucose-resistant hemagglutination was also more common in A. sobria, but invasive strains were equally divided between fucose-resistant hemagglutination and other patterns. Detailed clinical information was available for 27 of the 69 strains. All 15 strains of A. sobria or A. hydrophila associated with diarrhea were enterotoxigenic; 6 of the 10 strains of A. sobria were also invasive. Blood was present in the stool samples of five of the six patients with invasive A. sobria and in none of the patients with noninvasive strains. Although limited, these observations suggest that dysenteric symptoms may be produced by invasive Aeromonas spp.
在69株气单胞菌属粪便分离株中，18株具有侵袭人肝癌细胞（HEp - 2）的能力。侵袭性与生物型相关；在这18株侵袭性菌株中，16株为温和气单胞菌，2株为嗜水气单胞菌。豚鼠气单胞菌中未发现侵袭性菌株。在这18株侵袭性菌株中，13株产生肠毒素。在产肠毒素和具有侵袭性的菌株中，12株为温和气单胞菌，但肠毒素产生在温和气单胞菌的非侵袭性菌株中也较为常见。抗岩藻糖血凝反应在温和气单胞菌中也更常见，但侵袭性菌株在抗岩藻糖血凝反应和其他模式之间平分。69株菌株中有27株有详细的临床信息。所有15株与腹泻相关的温和气单胞菌或嗜水气单胞菌菌株均产肠毒素；10株温和气单胞菌中有6株也具有侵袭性。6例侵袭性温和气单胞菌患者中有5例粪便样本中有血，而无侵袭性菌株的患者粪便样本中均无血。尽管这些观察结果有限，但表明痢疾症状可能由侵袭性气单胞菌属产生。
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