肌肉减少症与胃肠道癌症：聚焦姜黄素补充的营养方法

SARCOPENIA AND GASTROINTESTINAL CANCER: NUTRITIONAL APPROACH FOCUSING ON CURCUMIN SUPPLEMENTATION.

作者信息

Almeida Pamela S de, Barão Katia, Forones Nora M

机构信息

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, Divisão de Gastroenterologia, São Paulo, SP, Brasil.

出版信息

Arq Gastroenterol. 2025 Apr 4;62:e24068. doi: 10.1590/S0004-2803.24612024-068. eCollection 2025.

DOI:10.1590/S0004-2803.24612024-068

PMID:40197883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12043197/

Abstract

BACKGROUND

Sarcopenia is a syndrome characterized by decreased strength, quantity and/or quality of skeletal muscle mass. When associated with cancer, it correlates with poorer clinical outcomes. Cancers of the gastrointestinal tract, prevalent globally and in Brazil, are associated with a greater nutritional risk. Early detection and intervention for nutritional risks are critical in this population. Recent studies on turmeric/curcumin have demonstrated beneficial effects in cancer patients. Specifically, curcumin have shown promise in reducing muscle depletion, oxidative stress, and improving strength and fatigue, factors related to sarcopenia. This review aims to elucidate sarcopenia and sarcopenia secondary to cancer, emphasizing nutritional management and the role of curcumin supplementation. Effective cancer management, whether with or without sarcopenia, demands comprehensive public health strategies and multimodal interventions within healthcare institutions. Nutrition is pivotal across the cancer care journey, encompassing screening, guidance, and provision of nutrients that support maintaining or recovering body composition. Curcumin supplementation emerges as a potential adjuvant to the standard cancer treatment and sarcopenia management. Nevertheless, further clinical studies are warranted to substantiate these findings.

BACKGROUND

• Sarcopenia is a syndrome characterized by decreased strength, quantity and/or quality of skeletal muscle mass.

BACKGROUND

• Sarcopenia when associated with cancer, it correlates with poorer clinical outcomes.

BACKGROUND

• Curcumin has shown promise in reducing muscle depletion, oxidative stress, and improving strength and fatigue, factors related to sarcopenia.

BACKGROUND

• Curcumin supplementation emerges as a potential adjuvant to the standard cancer treatment and sarcopenia management.

摘要

背景

肌肉减少症是一种以骨骼肌质量的力量、数量和/或质量下降为特征的综合征。当与癌症相关时，它与较差的临床结果相关。胃肠道癌症在全球和巴西都很普遍，与更高的营养风险相关。对这一人群来说，早期发现和干预营养风险至关重要。最近关于姜黄/姜黄素的研究表明其对癌症患者有有益作用。具体而言，姜黄素在减少肌肉消耗、氧化应激以及改善力量和疲劳方面显示出前景，这些都是与肌肉减少症相关的因素。本综述旨在阐明肌肉减少症以及癌症继发的肌肉减少症，强调营养管理和补充姜黄素的作用。有效的癌症管理，无论是否伴有肌肉减少症，都需要全面的公共卫生策略和医疗机构内的多模式干预。营养在整个癌症治疗过程中至关重要，包括筛查、指导以及提供支持维持或恢复身体组成的营养素。补充姜黄素成为标准癌症治疗和肌肉减少症管理的潜在辅助手段。然而，需要进一步的临床研究来证实这些发现。