感染白血病病毒的大鼠细胞中复制后修复的部分抑制及化学转化频率的提高。
Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus.
作者信息
Waters R, Mishra N, Bouck N, DiMayorca G, Regan J D
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):238-42. doi: 10.1073/pnas.74.1.238.
Abstract
Postreplication repair of DNA and chemical transformation with the carcinogen 4-nitroquinoline-1-oxide were studied in rat cell lines either uninfected or infected with Rauscher leukemia virus. The results indicate that equivalent amounts of carcinogen are bound to the DNA initially and removed during excision repair. However, the lines differ in that the infected line alone exhibits both sensitivity to nitroquinoline-oxide-induced transformation and a partial inhibition of the postreplication repair process after notroquinoline oxide or UV treatment.
摘要
对未感染或感染劳斯氏白血病病毒的大鼠细胞系进行了DNA复制后修复以及用致癌物4-硝基喹啉-1-氧化物进行化学转化的研究。结果表明，等量的致癌物最初与DNA结合，并在切除修复过程中被去除。然而，这些细胞系的不同之处在于，仅感染的细胞系既对硝基喹啉氧化物诱导的转化敏感，又在经硝基喹啉氧化物或紫外线处理后对复制后修复过程有部分抑制作用。
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