感染白血病病毒的大鼠细胞中复制后修复的部分抑制及化学转化频率的提高。
Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus.
作者信息
Waters R, Mishra N, Bouck N, DiMayorca G, Regan J D
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):238-42. doi: 10.1073/pnas.74.1.238.
Abstract
Postreplication repair of DNA and chemical transformation with the carcinogen 4-nitroquinoline-1-oxide were studied in rat cell lines either uninfected or infected with Rauscher leukemia virus. The results indicate that equivalent amounts of carcinogen are bound to the DNA initially and removed during excision repair. However, the lines differ in that the infected line alone exhibits both sensitivity to nitroquinoline-oxide-induced transformation and a partial inhibition of the postreplication repair process after notroquinoline oxide or UV treatment.
摘要
对未感染或感染劳斯氏白血病病毒的大鼠细胞系进行了DNA复制后修复以及用致癌物4-硝基喹啉-1-氧化物进行化学转化的研究。结果表明，等量的致癌物最初与DNA结合，并在切除修复过程中被去除。然而，这些细胞系的不同之处在于，仅感染的细胞系既对硝基喹啉氧化物诱导的转化敏感，又在经硝基喹啉氧化物或紫外线处理后对复制后修复过程有部分抑制作用。
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本文引用的文献
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Virology. 1964 Jun;23:291-4. doi: 10.1016/0042-6822(64)90301-0.
2
One-step growth curve of Western equine encephalomyelitis virus on chicken embryo cells grown in vitro and analysis of virus yields from single cells.西部马脑炎病毒在体外培养的鸡胚细胞上的一步生长曲线及单细胞病毒产量分析
J Exp Med. 1954 Feb;99(2):183-99. doi: 10.1084/jem.99.2.183.
3
Defective repair replication of DNA in xeroderma pigmentosum.着色性干皮病中DNA修复复制缺陷。
Nature. 1968 May 18;218(5142):652-6. doi: 10.1038/218652a0.
4
Normal and defective repair of damaged DNA in human cells: a sensitive assay utilizing the photolysis of bromodeoxyuridine.人类细胞中受损DNA的正常与缺陷修复：一种利用溴脱氧尿苷光解作用的灵敏检测方法。
Proc Natl Acad Sci U S A. 1971 Apr;68(4):708-12. doi: 10.1073/pnas.68.4.708.
5
Evidence that xeroderma pigmentosum cells do not perform the first step in the repair of ultraviolet damage to their DNA.着色性干皮病细胞在修复其DNA紫外线损伤时不执行第一步的证据。
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6
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Anal Biochem. 1971 Oct;43(2):427-32. doi: 10.1016/0003-2697(71)90272-7.
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