鼻黏膜自主神经反应在翼管神经切断术治疗变应性鼻炎疗效评估中的应用：一项前瞻性研究
Use of nasal mucosal autonomic nerve response in efficacy evaluation of vidian neurectomy for allergic rhinitis: a prospective study.
作者信息
Liu Linzheng, Ma Na, Niu Yan, Peng Yuping, Li Yan, Shen Jiangjiang, He Jiameng, Sun Jindi
机构信息
Department of Otolaryngology Head and Neck Surgery, Yulin City First Hospital of Yan'an University, Yulin, China.
Department of Otolaryngology Head and Neck Surgery, Yan'an University, Yan'an, China.
出版信息
Front Neurosci. 2025 Mar 25;19:1424629. doi: 10.3389/fnins.2025.1424629. eCollection 2025.
OBJECTIVE
To evaluate the use of nasal mucosal autonomic nerve responses as an objective indicator for assessing the efficacy of vidian neurectomy (VN) in treating allergic rhinitis (AR).
METHODS
Thirty-five patients with moderate to severe AR and 35 healthy controls were included. Autonomic nerve responses were measured before and 1 month after VN surgery, using respiratory stimulation on the nasal mucosa and the opisthenar area. Three waveform types (P-type, N-type and M-type) were identified.
RESULTS
While three waveform types were identified in the nasal mucosa, only the M-type was observed in the opisthenar sympathetic skin response. Preoperative measurements showed higher autonomic responses in patients with AR compared with controls. Following VN, the responses in patients with AR decreased significantly, aligning closely with the control group. No significant changes were observed in the opisthenar responses, indicating a localised effect of VN. Comorbidities such as nasal polyps, sinusitis and deviated septum did not impact the results.
CONCLUSION
Nasal mucosal autonomic nerve response provides a reliable, objective measure for evaluating the effectiveness of VN in treating AR.
目的
评估鼻黏膜自主神经反应作为评估翼管神经切断术（VN）治疗变应性鼻炎（AR）疗效的客观指标的应用价值。
方法
纳入35例中重度AR患者和35例健康对照者。在VN手术前及术后1个月，通过对鼻黏膜和小鱼际区域进行呼吸刺激来测量自主神经反应。识别出三种波形类型（P型、N型和M型）。
结果
虽然在鼻黏膜中识别出三种波形类型，但在小鱼际交感皮肤反应中仅观察到M型。术前测量显示，AR患者的自主神经反应高于对照组。VN术后，AR患者的反应显著降低，与对照组密切一致。小鱼际反应未观察到显著变化，表明VN具有局部效应。鼻息肉、鼻窦炎和鼻中隔偏曲等合并症不影响结果。
结论
鼻黏膜自主神经反应为评估VN治疗AR的有效性提供了可靠的客观指标。
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