Yang Lin, Yi Xue, Duan Meitao, Mahal Ahmed, Chen Binbin, Zhang Zhiqiang, Ren Jungang, Chen Ming, Meng Chen, Xu Moxun, Obaidullah Ahmad J, Wang Chen, Liu Mingyuan
College of Pharmacy, Jiamusi University, Jiamusi, China.
Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian Province University, Xiamen, China.
Front Pharmacol. 2025 Mar 25;16:1560462. doi: 10.3389/fphar.2025.1560462. eCollection 2025.
Exosomes released from cells have been shown to play an important role in health and disease due to their potential application in therapy and diagnosis. First of all, we extracted the exosome from Phascolosoma esculenta, and studied the lipid lowering and antioxidant activity of Phascolosoma esculenta exosome. It was found that Phascolosoma esculenta exosomes could significantly decrease the lipid accumulation caused by oleic acid, and improve triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C). The exosomes of Phascolosoma esculenta also exhibit antioxidant activity, which can decrease the amount of reactive oxygen species (ROS) and malondialdehyde (MDA), and raise the level of superoxide dismutase (SOD) and total antioxidant capacity (T-AOC). The exosomes of Phascolosoma esculenta have the function of reducing lipid and antioxidation.
细胞释放的外泌体因其在治疗和诊断中的潜在应用，已被证明在健康和疾病中发挥重要作用。首先，我们从可口革囊星虫中提取了外泌体，并研究了可口革囊星虫外泌体的降脂和抗氧化活性。研究发现，可口革囊星虫外泌体可显著减少油酸引起的脂质积累，并改善甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白（LDL-C）水平。可口革囊星虫外泌体还具有抗氧化活性，可减少活性氧（ROS）和丙二醛（MDA）的含量，并提高超氧化物歧化酶（SOD）水平和总抗氧化能力（T-AOC）。可口革囊星虫外泌体具有降脂和抗氧化功能。
