Darwish Asmaa A
Animal Health and Poultry Department, Animal Production and Poultry Division, Desert Research Center (DRC), Cairo, Egypt.
Open Vet J. 2025 Feb;15(2):901-910. doi: 10.5455/OVJ.2025.v15.i2.39. Epub 2025 Feb 28.
Ovine mange is a highly transmissible skin condition that typically results in significant economiclosses.
This research explored the clinicopathological alterations associated with mange in Barki sheep and evaluated the impact of integrating probiotics (ZAD) into the treatment protocol. Additionally, the study proposed diagnostic markers and indicators for assessing treatment prognosis.
Twenty healthy lambs [control group (CG)] and 20 lambs suffered from mange symptoms (confirmed by skin scrapings) in the diseased group (DG). DG was divided into two groups: the traditional group (TG) was injected once with 1 ml/50 kg ivermectin 1% (Promectine, Invesa) subcutaneously injected + topical Zinc ointment, and the ZAD Group (ZG): received the same treatment + 5 ml/ head of ZAD orally, repeated daily for 3 weeks. Skin scraping was repeated weekly until complete curing in both groups. Blood samples were collected from CG, DG (before treatment), and TG and ZG (after recovery).
DG (compared to CG) showed a significant ( < 0.05) innate immune response with hypercortisolemia and hypoinsulinemia, microcytic hypochromic anemia with leukocytosis and lymphocytopenia, hypoglycemia, hypoalbuminemia, hyperglobulinemia, hyperlipidemia, elevated liver and kidney function tests, decreased minerals and electrolytes, and hypozincemia. After treatment, the clinical symptoms and lesions completely recovered, and most of the estimated parameters reobtain their physiological ranges in TG and ZG on the 21st day. ZAD did not significantly impact the recovery or regression of lesions, but it markedly improved the diseased animals body weights and serum glucose in ZG (compared to CG and TG). Total antioxidant capacity (TAC), interleukin-1β (IL-1β), and ferritin had the highest likelihood ratios among the estimated markers.
Ovine scabies can lead to systemic and clinicopathological changes, necessitating careful monitoring and intervention. Adding ZAD to the treatment of mangy sheep might help enhance their body weights and serum glucose levels, but it does not affect the healing or reduction of lesions. TAC and IL-1β serve as dependable indicators for diagnosing ovine scabies, whereas TAC and ferritin are valuable for evaluating treatment effectiveness.
绵羊疥癣是一种高度传染性的皮肤疾病，通常会导致重大经济损失。
本研究探讨了巴尔基羊疥癣相关的临床病理变化，并评估了将益生菌（ZAD）纳入治疗方案的影响。此外，该研究提出了用于评估治疗预后的诊断标志物和指标。
20只健康羔羊[对照组（CG）]和20只患有疥癣症状的羔羊（经皮肤刮片确诊）作为患病组（DG）。DG分为两组：传统组（TG）皮下注射一次1%伊维菌素1 ml/50 kg（Promectine，Invesa）+外用锌软膏，ZAD组（ZG）：接受相同治疗+口服5 ml/只ZAD，每天重复，持续3周。两组每周重复进行皮肤刮片，直至完全治愈。从CG、DG（治疗前）以及TG和ZG（恢复后）采集血样。
与CG相比，DG表现出显著（<0.05）的先天性免疫反应，伴有高皮质醇血症和低胰岛素血症、小细胞低色素性贫血伴白细胞增多和淋巴细胞减少、低血糖、低白蛋白血症、高球蛋白血症、高脂血症、肝功能和肾功能检查升高、矿物质和电解质降低以及低锌血症。治疗后，临床症状和病变完全恢复，在第21天，TG和ZG中的大多数估计参数恢复到生理范围。ZAD对病变的恢复或消退没有显著影响，但与CG和TG相比，它显著提高了ZG中患病动物的体重和血糖。在估计的标志物中，总抗氧化能力（TAC）、白细胞介素-1β（IL-1β）和铁蛋白具有最高的似然比。
绵羊疥癣可导致全身和临床病理变化，需要仔细监测和干预。在患疥癣绵羊的治疗中添加ZAD可能有助于提高它们的体重和血糖水平，但不影响病变的愈合或减轻。TAC和IL-1β是诊断绵羊疥癣的可靠指标，而TAC和铁蛋白对评估治疗效果有价值。
