Sharaf Mahmoud S
Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Gharbia, Egypt.
Parasitol Res. 2024 Mar 4;123(3):149. doi: 10.1007/s00436-024-08173-6.
Scabies is an itchy skin disease caused by the burrowing mite Sarcoptes scabiei. During their lifespan, the female mites invade the stratum corneum and create tunnels, in which they reside, move, feed, deposit fecal pellets, and lay eggs. Recently, scabies was included in the World Health Organization roadmap for neglected tropical diseases 2021-2030. This review attempts to summarize our knowledge about the mite's biology and the disease pathogenesis, pathological changes, and complications. Generally, the host-parasite interaction in scabies is highly complex and involves different mechanisms, some of which are yet largely unknown. Elucidation of the nature of such interaction as well as the underlying mechanisms could allow a better understanding of the mite's biology and the development of novel diagnostic and therapeutic options for scabies control programs. Moreover, identification of the molecular basis of such interaction could unveil novel targets for acaricidal agents and vaccines.
疥疮是由疥螨钻入皮肤引起的一种瘙痒性皮肤病。在其生命周期中，雌螨侵入角质层并形成隧道，它们在其中生存、移动、进食、排泄粪便颗粒并产卵。最近，疥疮被纳入世界卫生组织2021 - 2030年被忽视热带病路线图。本综述试图总结我们对疥螨生物学以及疾病发病机制、病理变化和并发症的认识。一般来说，疥疮中的宿主 - 寄生虫相互作用非常复杂，涉及不同机制，其中一些机制在很大程度上仍不为人知。阐明这种相互作用的性质及其潜在机制有助于更好地了解疥螨生物学，并为疥疮控制计划开发新的诊断和治疗方法。此外，确定这种相互作用的分子基础可以揭示杀螨剂和疫苗的新靶点。
