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用于递送营养剂的聚合物瘤胃稳定递送系统。

Polymeric rumen-stable delivery systems for delivering nutricines.

作者信息

Herdiana Yedi

机构信息

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.

Veterinary Pharmaceutical Development Group, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.

出版信息

Open Vet J. 2025 Feb;15(2):565-593. doi: 10.5455/OVJ.2025.v15.i2.7. Epub 2025 Feb 28.

DOI:10.5455/OVJ.2025.v15.i2.7
PMID:40201846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11974284/
Abstract

Ruminants face unique drug and nutrient delivery challenges because of their symbiotic rumen microorganisms. Polymeric rumen-stable delivery systems (RDSs) have emerged as a promising solution for efficiently delivering nutrition and enhancing animal health and productivity. Traditional methods such as heat and chemical treatment have been improved with polymeric coatings that facilitate the slow postruminal release of bioactive substances. Polymeric coatings of nutrients offer significant potential for improving ruminant health, reducing farmer costs, and promoting sustainability in livestock. This paper explores the mechanisms of rumen protection and abomasal release provided by polymeric coatings, discusses other RSDs, and reviews methods for evaluating their performance and . Further research in this area could advance novel nutricine delivery solutions for ruminants.

摘要

由于反刍动物存在共生的瘤胃微生物，它们面临着独特的药物和营养物质递送挑战。聚合物瘤胃稳定递送系统（RDSs）已成为一种有前景的解决方案，可有效递送营养物质并增强动物健康和生产力。诸如加热和化学处理等传统方法已通过聚合物涂层得到改进，这些涂层有助于生物活性物质在瘤胃后缓慢释放。营养物质的聚合物涂层在改善反刍动物健康、降低养殖成本和促进畜牧业可持续发展方面具有巨大潜力。本文探讨了聚合物涂层提供的瘤胃保护和皱胃释放机制，讨论了其他RSDs，并综述了评估其性能的方法。该领域的进一步研究可能会推动针对反刍动物的新型营养药物递送解决方案的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/3ac7bdef7d01/OpenVetJ-15-565-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/9513a80e9def/OpenVetJ-15-565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/3c84259dd85b/OpenVetJ-15-565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/7453e2c10be9/OpenVetJ-15-565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/e4ffb2e832f8/OpenVetJ-15-565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/cc51a2ead130/OpenVetJ-15-565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/9d64a3170126/OpenVetJ-15-565-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/3ac7bdef7d01/OpenVetJ-15-565-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/9513a80e9def/OpenVetJ-15-565-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/3c84259dd85b/OpenVetJ-15-565-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/7453e2c10be9/OpenVetJ-15-565-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/e4ffb2e832f8/OpenVetJ-15-565-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/cc51a2ead130/OpenVetJ-15-565-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/9d64a3170126/OpenVetJ-15-565-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1704/11974284/3ac7bdef7d01/OpenVetJ-15-565-g007.jpg

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