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来自树叶的类黄酮通过调节高脂饮食喂养小鼠的糖脂水平、氧化应激和肠道细菌组成来减轻肥胖。

Flavonoids from leaves attenuate obesity through modulating glycolipid levels, oxidative stress, and gut bacterial composition in high-fat diet-fed mice.

作者信息

Liao JiaLe, Guo Jia, Niu YinHong, Fang Tian, Wang FangZhou, Fan YanLi

机构信息

Department of Food Science and Technology, School of Food & Wine, Ningxia University, Yinchuan, China.

Ningxia Red Power Goji Co., Ltd., Zhongwei, China.

出版信息

Front Nutr. 2022 Jul 28;9:972794. doi: 10.3389/fnut.2022.972794. eCollection 2022.

DOI:10.3389/fnut.2022.972794
PMID:35967795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9366397/
Abstract

Traditional herbal therapy made from leaves has been said to be effective in treating metabolic diseases, while its exact processes are yet unknown. Natural flavonoids are considered as a secure and reliable method for treating obesity. We thus made an effort to investigate the processes by which flavonoids from leaves (LBLF) reduce obesity. To assess the effectiveness of the intervention following intragastric injection of various dosages of LBLF (50, 100, and 200 mg/kg⋅bw), obese model mice developed via a high-fat diet were utilized. Treatment for LBLF may decrease body weight gain, Lee's index, serum lipids levels, oxidative stress levels, and hepatic lipids levels. It may also enhance fecal lipids excretion and improve glucose tolerance. Additionally, LBLF therapy significantly restored gut dysfunction brought on by a high-fat diet by boosting gut bacterial diversities and altering the composition of the gut bacterial community by elevating probiotics and reducing harmful bacteria.

摘要

由树叶制成的传统草药疗法据说对治疗代谢疾病有效，但其确切过程尚不清楚。天然黄酮类化合物被认为是治疗肥胖症的一种安全可靠的方法。因此，我们努力研究树叶中的黄酮类化合物（LBLF）减轻肥胖的过程。为了评估胃内注射不同剂量的LBLF（50、100和200mg/kg·bw）后干预措施的有效性，我们使用了通过高脂饮食建立的肥胖模型小鼠。LBLF治疗可能会减少体重增加、李氏指数、血脂水平、氧化应激水平和肝脏脂质水平。它还可能增加粪便脂质排泄并改善葡萄糖耐量。此外，LBLF疗法通过增加肠道细菌多样性以及通过增加益生菌和减少有害细菌来改变肠道细菌群落组成，显著恢复了高脂饮食引起的肠道功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/b8a9ff3e6347/fnut-09-972794-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/192eeea9613c/fnut-09-972794-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/c576a66e3379/fnut-09-972794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/6cd089d524d3/fnut-09-972794-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/ac510fb97c4c/fnut-09-972794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/e7364720db4e/fnut-09-972794-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/b8a9ff3e6347/fnut-09-972794-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/192eeea9613c/fnut-09-972794-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/94b81463205e/fnut-09-972794-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/6eb42d73d269/fnut-09-972794-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/c576a66e3379/fnut-09-972794-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/6cd089d524d3/fnut-09-972794-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/ac510fb97c4c/fnut-09-972794-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/e7364720db4e/fnut-09-972794-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a06a/9366397/b8a9ff3e6347/fnut-09-972794-g008.jpg

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