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Genetic variants associated with physiological and biochemical indicators: A multi-centre whole-exome sequencing study of Chinese healthy participants.

作者信息

Wang Zhe, Liu Zhiyan, Mu Guangyan, Xie Qiufen, Zhou Shuang, Wang Zining, Cui Yimin, Xiang Qian

机构信息

Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.

Department of Pharmacy, Peking University First Hospital, Beijing, China.

出版信息

Clin Transl Med. 2025 Apr;15(4):e70300. doi: 10.1002/ctm2.70300.

DOI:10.1002/ctm2.70300
PMID:40205807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982517/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/4971808c4df2/CTM2-15-e70300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/354acdcadf3f/CTM2-15-e70300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/5fc2661ce6a5/CTM2-15-e70300-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/4971808c4df2/CTM2-15-e70300-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/354acdcadf3f/CTM2-15-e70300-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/5fc2661ce6a5/CTM2-15-e70300-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa46/11982517/4971808c4df2/CTM2-15-e70300-g002.jpg

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本文引用的文献

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The Pharmacogenetic Variability Associated with the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Healthy Chinese Subjects: A National Multicenter Exploratory Study.利伐沙班在中国健康受试者药代动力学和药效学的药物遗传学变异性：一项全国多中心探索性研究。
Clin Ther. 2024 Apr;46(4):313-321. doi: 10.1016/j.clinthera.2024.02.009. Epub 2024 Mar 28.
2
Identification of genetic biomarkers associated with pharmacokinetics and pharmacodynamics of apixaban in Chinese healthy volunteers.鉴定与阿哌沙班在中国健康志愿者中的药代动力学和药效学相关的遗传生物标志物。
Expert Opin Drug Metab Toxicol. 2023 Jan;19(1):43-51. doi: 10.1080/17425255.2023.2184344. Epub 2023 Mar 3.
3
, , and Genetic Variations Associated With Dabigatran Metabolism in a Healthy Chinese Population.
健康中国人群中与达比加群代谢相关的基因变异
Front Genet. 2022 May 13;13:873031. doi: 10.3389/fgene.2022.873031. eCollection 2022.
4
Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects.含 NUP153 和 SVEP1 基因多态性对健康中国受试者中美托洛尔药代动力学和药效学的影响。
Clin Drug Investig. 2022 May;42(5):447-458. doi: 10.1007/s40261-022-01154-6. Epub 2022 Apr 30.
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The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease.东亚悖论：心血管疾病患者当前抗栓策略面临挑战的最新立场声明。
Thromb Haemost. 2021 Apr;121(4):422-432. doi: 10.1055/s-0040-1718729. Epub 2020 Nov 10.
6
Comparison of heritability of Cystatin C- and creatinine-based estimates of kidney function and their relation to heritability of cardiovascular disease.基于胱抑素C和肌酐的肾功能估计值的遗传力比较及其与心血管疾病遗传力的关系。
J Am Heart Assoc. 2015 Jan 14;4(1):e001467. doi: 10.1161/JAHA.114.001467.
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Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.在循环中 LDL 水平较低的个体中，发现一种 LDL 受体变异体的功能丧失诱导降解剂。
Eur Heart J. 2013 May;34(17):1292-7. doi: 10.1093/eurheartj/ehs472. Epub 2013 Jan 16.
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Hepatology. 2010 Nov;52(5):1836-46. doi: 10.1002/hep.24001.
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