Yu Di, Hu Yibo, Ma Meijuan, Li Wenjia, Zhao Xiaohui
Department of Basic Medical Sciences, Qinghai Unversity Medical College, Xining, Qinghai, China.
Department of Orthopaedic Trauma, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
Front Pharmacol. 2025 Mar 26;16:1519000. doi: 10.3389/fphar.2025.1519000. eCollection 2025.
Ferroptosis is a newly identified type of iron-dependent cell death that characterized by an increase in intracellular iron ions, which disrupt the balance of the cellular lipid peroxidation system, causing lipid peroxidation and ultimately resulting in cell death. Interestingly, ferroptosis is modulated by hypoxia and plays a role in hypoxia-related diseases. Therefore, we performed a bibliometric review of the Web of Science Core Collection (WoSCC) database to investigate the link between ferroptosis and hypoxia from January 2013 to December 2023.
The core collection within the Web of Science bibliographic index was consulted to extract relevant articles and reviews. Data on publications, countries, institutions, authors, journals, citations, and keywords in the included studies were systematically analyzed using Microsoft Excel 2019 and CiteSpace 6.3.R1 software.
A comprehensive analysis and visualization of 472 research papers on ferroptosis under hypoxic conditions published between 2013 and 2023 revealed emerging research hotspots and trends. Initially, a scarcity of studies existed in this field. However, this was succeeded by a significant increase in research interest in subsequent years, culminating in a peak of 204 publications in 2023. Research in this field focused primarily on the Asian region. Notably, research hotspots include diseases related to hypoxia, treatment therapy and pathogenesis. Among the researchers in this field, Supuran emerged as the most prolific author. Wuhan University was the leading institution in terms of research output, and China was the most prolific country in this area of study. Among the top ten journals ranked by the number of publications, nine were classified as Q1, indicating the high level of credibility of these studies. The research conducted by Stockwell et al., featured in the journal "," currently has the most citations. Present scholarly pursuits are primarily focused on comprehending the mechanisms through which interventions affect hypoxia-related diseases through the ferroptosis pathway, as well as on probing and pinpointing prospective treatment targets.
This study highlights key areas of interest and emerging trends in ferroptosis research in the presence of hypoxic conditions, thus providing valuable insights for future directions of exploration for the diagnosis and treatment of hypoxia-related diseases.
铁死亡是一种新发现的铁依赖性细胞死亡类型，其特征是细胞内铁离子增加，这会破坏细胞脂质过氧化系统的平衡，导致脂质过氧化并最终导致细胞死亡。有趣的是，铁死亡受缺氧调节，并在缺氧相关疾病中起作用。因此，我们对科学网核心合集（WoSCC）数据库进行了文献计量学综述，以研究2013年1月至2023年12月期间铁死亡与缺氧之间的联系。
查阅科学网文献索引中的核心合集，以提取相关文章和综述。使用Microsoft Excel 2019和CiteSpace 6.3.R1软件对纳入研究中的出版物、国家、机构、作者、期刊、引用和关键词数据进行系统分析。
对2013年至2023年期间发表的472篇关于缺氧条件下铁死亡的研究论文进行的综合分析和可视化揭示了新出现的研究热点和趋势。最初，该领域的研究较少。然而，随后几年研究兴趣显著增加，在2023年达到204篇出版物的峰值。该领域的研究主要集中在亚洲地区。值得注意的是，研究热点包括与缺氧相关的疾病、治疗方法和发病机制。在该领域的研究人员中，苏普兰是发文量最多的作者。武汉大学是研究产出方面的领先机构，中国是该研究领域发文量最多的国家。在按出版物数量排名的前十种期刊中，有九种被归类为Q1，表明这些研究的可信度很高。斯托克韦尔等人在《》杂志上发表的研究目前被引用次数最多。目前的学术研究主要集中在理解干预措施通过铁死亡途径影响缺氧相关疾病的机制，以及探索和确定潜在的治疗靶点。
本研究突出了缺氧条件下铁死亡研究的关键关注领域和新出现的趋势，从而为缺氧相关疾病的诊断和治疗的未来探索方向提供了有价值的见解。
