Afzal Ali, Abbasi Muddasir Hassan, Ahmad Shaaf, Sheikh Nadeem, Khawar Muhammad Babar
Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan.
Department of Zoology, University of Okara, Okara, Pakistan.
Biomater Res. 2025 Apr 9;29:0178. doi: 10.34133/bmr.0178. eCollection 2025.
Messenger RNA (mRNA)-based therapy has revolutionized cancer research by enabling versatile delivery systems for therapeutic applications. The future of mRNA-based cancer therapies shows promise amidst challenges such as delivery efficiency, immunogenicity, and tumor heterogeneity. Recent progress has adapted various strategies such as design flexibility, scalable production, and targeted delivery capabilities to enhance the potential in personalized cancer therapy. Further research to optimize delivery for enhanced outcomes and efficacy in solid tumors is warranted. Therefore, we aim to explore the current landscape and future prospects of mRNA technology across various therapeutic platforms.
基于信使核糖核酸（mRNA）的疗法通过实现用于治疗应用的多功能递送系统，彻底改变了癌症研究。基于mRNA的癌症疗法的未来在递送效率、免疫原性和肿瘤异质性等挑战中展现出希望。最近的进展采用了各种策略，如设计灵活性、可扩展生产和靶向递送能力，以增强个性化癌症治疗的潜力。有必要进一步开展研究，以优化递送，从而在实体瘤中提高疗效和功效。因此，我们旨在探索mRNA技术在各种治疗平台上的当前状况和未来前景。
