Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Institute of Organoids on Chips Translational Research, Henan Academy of Sciences, Zhengzhou, 450009, China.
Adv Mater. 2024 Apr;36(15):e2308029. doi: 10.1002/adma.202308029. Epub 2024 Feb 8.
Messenger RNA (mRNA)-based therapeutic strategies have shown remarkable promise in preventing and treating a staggering range of diseases. Optimizing the structure and delivery system of engineered mRNA has greatly improved its stability, immunogenicity, and protein expression levels, which has led to a wider range of uses for mRNA therapeutics. Herein, a thorough analysis of the optimization strategies used in the structure of mRNA is first provided and delivery systems are described in great detail. Furthermore, the latest advancements in biomedical engineering for mRNA technology, including its applications in combatting infectious diseases, treating cancer, providing protein replacement therapy, conducting gene editing, and more, are summarized. Lastly, a perspective on forthcoming challenges and prospects concerning the advancement of mRNA therapeutics is offered. Despite these challenges, mRNA-based therapeutics remain promising, with the potential to revolutionize disease treatment and contribute to significant advancements in the biomedical field.
基于信使 RNA（mRNA）的治疗策略在预防和治疗各种疾病方面显示出了显著的前景。优化工程化 mRNA 的结构和递送系统极大地提高了其稳定性、免疫原性和蛋白表达水平，这使得 mRNA 治疗药物的应用范围更广。本文首先深入分析了 mRNA 结构优化策略，并详细描述了递送系统。此外，还总结了 mRNA 技术在生物医学工程方面的最新进展，包括其在抗击传染病、治疗癌症、提供蛋白质替代疗法、进行基因编辑等方面的应用。最后，对 mRNA 治疗药物发展所面临的挑战和前景进行了展望。尽管存在这些挑战，但基于 mRNA 的治疗方法仍然具有广阔的前景，有可能彻底改变疾病治疗方式，并为生物医学领域的重大进步做出贡献。
