Shen Kuiling, Feng Yuxin, Wang Changdong, Han Jingwan, Liu Yongjian, Jia Lei, Zhang Bohan, Wang Xiaolin, Li Jingyun, Liu Ziwei, Dai Erhei, Li Hanping, Li Lin, Yan Huimin
School of Public Health, Hebei Medical University, Shijiazhuang, Hebei, China.
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, China.
AIDS Res Hum Retroviruses. 2025 Jun;41(6):317-321. doi: 10.1089/aid.2024.0127. Epub 2025 Apr 10.
The global fight against human immunodeficiency virus (HIV) is complicated by its extensive genetic diversity, which arises from high mutation rates, rapid replication, and frequent recombination events. These factors lead to the emergence of numerous recombinant forms of HIV-1, contributing to the virus's adaptability and complicating prevention and treatment efforts. In this study, we identified two novel, unique recombinant forms (URFs) of HIV-1, CRF01_AE/CRF79_0107 and CRF01_AE/CRF07_BC, through near full-length genome sequence analysis. These URFs were detected in two individuals within the student men who have sex with men (MSM) population of Shijiazhuang, Hebei Province, China. Both utilized CRF01_AE as the underlying template, and PQ585802 represents a second-generation recombinant form comprising CRF01_AE and CRF79_0107. It is a novel recombinant form that was initially identified. PQ585803 represents a second-generation recombinant form, composed of CRF01_AE and CRF07_BC, and exhibits distinctive characteristics when compared to previously identified recombinant forms. This study underscores the urgent need for targeted public health measures focusing on high-risk populations, such as MSM and students, to curb the spread of HIV-1. Tailored education, enhanced access to prevention services, and strategies addressing risky behaviors are critical in reducing HIV-1 prevalence and mitigating the challenges posed by recombinant forms.
全球抗击人类免疫缺陷病毒（HIV）的斗争因该病毒广泛的基因多样性而变得复杂，这种多样性源于高突变率、快速复制以及频繁的重组事件。这些因素导致了众多HIV-1重组形式的出现，增强了病毒的适应性，也使预防和治疗工作变得更加复杂。在本研究中，我们通过近乎全长的基因组序列分析，鉴定出两种新型独特重组形式（URF）的HIV-1，即CRF01_AE/CRF79_0107和CRF01_AE/CRF07_BC。在中国河北省石家庄市男男性行为者（MSM）群体中的两名学生个体中检测到了这些URF。两者均以CRF01_AE作为基础模板，PQ585802代表一种由CRF01_AE和CRF79_0107组成的第二代重组形式。它是最初鉴定出的一种新型重组形式。PQ585803代表一种由CRF01_AE和CRF07_BC组成的第二代重组形式，与先前鉴定出的重组形式相比具有独特特征。本研究强调迫切需要针对男男性行为者和学生等高风险人群采取有针对性的公共卫生措施，以遏制HIV-1的传播。量身定制的教育、增加预防服务的可及性以及应对危险行为的策略对于降低HIV-1流行率和减轻重组形式带来的挑战至关重要。
