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单次灌肠粪便微生物群移植治疗猫慢性肠病

Single Enema Fecal Microbiota Transplantation in Cats With Chronic Enteropathy.

作者信息

Karra Dimitra A, Suchodolski Jan S, Newman Shelley J, Flouraki Evgenia, Lidbury Jonathan A, Steiner Joerg M, Xenoulis Panagiotis G

机构信息

Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece.

Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, Texas, USA.

出版信息

J Vet Intern Med. 2025 May-Jun;39(3):e70054. doi: 10.1111/jvim.70054.

DOI:10.1111/jvim.70054

PMID:40207935

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11983779/

Abstract

BACKGROUND

Chronic enteropathies (CE) are common in cats, and alterations of the intestinal microbiota might be involved in the pathogenesis.

HYPOTHESIS/OBJECTIVES: To evaluate the efficacy of a single enema fecal microbiota transplantation (FMT) in improving intestinal dysbiosis and clinical scores in cats with CE.

ANIMALS

Twenty-eight cats with either chronic inflammatory enteropathy (CIE; n = 19) or small cell gastrointestinal lymphoma (SCGL; n = 9) were prospectively enrolled.

METHODS

Eleven cats were randomly selected to receive a single enema FMT (FMT-group), and 17 cats were used as controls. Clinical activity was determined using the Feline Chronic Enteropathy Activity Index (FCEAI), and intestinal dysbiosis was determined using the feline dysbiosis index (DI) on the day of FMT (T0) and 30 days after FMT (T1).

RESULTS

At T0, 14/28 cats had an abnormal DI > 0. No significant difference was found in the DI from T0 to T1 in the FMT group (mean[SD]: 0.01[2.5] vs. 0.7[2.1]; p = 0.47). No significant difference was found in the DI between the FMT group and the control group at T1 (mean[SD]: -0.7[2.1] vs. 0.8[1.8]; p = 0.92). FCEAI significantly decreased at T1 compared to T0 in the FMT group (median[IQR] 10.0[7.7-11.3] vs. 4.5[4-5]; p = 0.002). No significant difference was found in the FCEAI between the FMT group and the control group at T1 (median[IQR] 4.5[4-5] vs. 4[3-5.75]; p = 0.64).

CONCLUSIONS

In this study, single enema FMT did not lead to a significant improvement in DI or FCEAI in cats with CE compared to controls.

摘要

背景

慢性肠病（CE）在猫中很常见，肠道微生物群的改变可能参与其发病机制。

假设/目的：评估单次灌肠粪便微生物群移植（FMT）对改善CE猫肠道菌群失调和临床评分的疗效。

动物

前瞻性纳入28只患有慢性炎症性肠病（CIE；n = 19）或小细胞胃肠淋巴瘤（SCGL；n = 9）的猫。

方法

随机选择11只猫接受单次灌肠FMT（FMT组），17只猫作为对照。在FMT当天（T0）和FMT后30天（T1），使用猫慢性肠病活动指数（FCEAI）确定临床活动度，使用猫菌群失调指数（DI）确定肠道菌群失调情况。

结果

在T₀时，28只猫中有14只的DI>0异常。FMT组从T₀到T₁的DI无显著差异（平均值[标准差]：0.01[2.5]对0.7[2.1]；p = 0.47）。在T₁时，FMT组和对照组之间的DI无显著差异（平均值[标准差]：-0.7[2.1]对0.8[1.8]；p = 0.92）。与T₀相比，FMT组在T₁时FCEAI显著降低（中位数[四分位间距]10.0[7.7 - 11.3]对4.5[4 - 5]；p = 0.002）。在T₁时，FMT组和对照组之间的FCEAI无显著差异（中位数[四分位间距]4.5[4 - 5]对4[3 - 5.75]；p = 0.64）。