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放射组学模型性能评估中固定比例数据分割的陷阱。

The pitfalls of fixed-ratio data splitting in radiomics model performance evaluation.

作者信息

Wang Haoru

机构信息

Department of Radiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China.

出版信息

Abdom Radiol (NY). 2025 Apr 10. doi: 10.1007/s00261-025-04936-6.

DOI:10.1007/s00261-025-04936-6
PMID:40208285
Abstract

Over the past decade, radiomics has seen exponential growth, with over ten thousand publications in PubMed and a steady increase in related studies in journals like Abdominal Radiology. Despite the potential of radiomics, a major challenge lies in validating radiomics models, as most studies rely on single-center datasets with fixed-ratio splits, which can lead to variability in performance due to randomness in data splitting. Therefore, researchers should adopt more robust cross-validation methods rather than relying solely on the fixed-ratio holdout method to ensure robust and reliable radiomics model performance evaluation.

摘要

在过去十年中,放射组学呈指数级增长,在PubMed上有一万多篇相关出版物,并且在《腹部放射学》等期刊上的相关研究也在稳步增加。尽管放射组学具有潜力,但一个主要挑战在于验证放射组学模型,因为大多数研究依赖于具有固定比例划分的单中心数据集,这可能由于数据划分的随机性而导致性能的变异性。因此,研究人员应采用更稳健的交叉验证方法,而不是仅仅依赖于固定比例的留出法,以确保对放射组学模型性能进行稳健且可靠的评估。

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本文引用的文献

1
Role of radiomics as a predictor of disease recurrence in ovarian cancer: a systematic review.基于放射组学的卵巢癌疾病复发预测作用的系统综述。
Abdom Radiol (NY). 2024 Oct;49(10):3540-3547. doi: 10.1007/s00261-024-04330-8. Epub 2024 May 15.
2
Radiomics in CT and MR imaging of the liver and pancreas: tools with potential for clinical application.肝脏和胰腺 CT 和 MRI 影像中的放射组学:具有临床应用潜力的工具。
Abdom Radiol (NY). 2024 Jan;49(1):322-340. doi: 10.1007/s00261-023-04071-0. Epub 2023 Oct 27.
3
A Guide to Cross-Validation for Artificial Intelligence in Medical Imaging.
医学成像中人工智能的交叉验证指南
Radiol Artif Intell. 2023 May 24;5(4):e220232. doi: 10.1148/ryai.220232. eCollection 2023 Jul.
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Contrast-enhanced computed tomography radiomics in predicting primary site response to neoadjuvant chemotherapy in high-risk neuroblastoma.对比增强计算机断层扫描影像组学在预测高危神经母细胞瘤新辅助化疗的原发灶反应中的应用
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Radiother Oncol. 2015 Mar;114(3):345-50. doi: 10.1016/j.radonc.2015.02.015. Epub 2015 Mar 4.
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Eur J Cancer. 2012 Mar;48(4):441-6. doi: 10.1016/j.ejca.2011.11.036. Epub 2012 Jan 16.
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