Singh Nameirakpam Bunindro, Singh Kabrambam Dasanta, Koijam Arunkumar S, Chakravorty Jharna, Jena Sarita, Chawla Saurabh, Mukherjee Pulok Kumar, Rajashekar Yallappa
Insect Resources Laboratory, Animal Resources Programme, Institute of Bioresources and Sustainable Development, Department of Biotechnology, Govt. Of India, Takyelpat, Imphal, Manipur, 795001, India.
Department of Zoology, Rajiv Gandhi University, Itanagar, Arunachal Pradesh, 781014, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 10. doi: 10.1007/s00210-025-04100-3.
Isosecotanapartholide (ISTP) isolated from Artemisia vulgaris, having fumigant property, was tested for acute and sub-acute toxicity in BALB/c mice. The male and female BALB/c mice were given ISTP orally for 7 days at doses of 200, 800 and 1600 mg/kg body weight (bw) for the acute toxicity assay. For sub-acute toxicity test, ISTP was given orally for 14 days at doses of 50 and 500 mg/kg bw. The general appearance, behaviour, weight gain, water intake and feed intake, relative organ weight, haematological indices, histopathological sections and biochemical markers were examined. In the study, ISTP at doses up to 1600 mg/kg bw in acute and 500 mg/kg bw in sub-acute studies, the vital organs like heart, kidney, uterus and testis revealed no adverse effects and mortality. Both acute and sub-acute toxicity assays show that Isosecotanapartholide is safe in mammalian system and can be used as an effective natural substitute for synthetic insecticides.
从艾草中分离出的具有熏蒸特性的异戊二烯愈创木内酯（ISTP），在BALB/c小鼠中进行了急性和亚急性毒性测试。在急性毒性试验中，将雄性和雌性BALB/c小鼠按200、800和1600毫克/千克体重（bw）的剂量口服ISTP 7天。对于亚急性毒性试验，ISTP按50和500毫克/千克体重的剂量口服14天。检查了一般外观、行为、体重增加、水摄入量和饲料摄入量、相对器官重量、血液学指标、组织病理学切片和生化标志物。在该研究中，在急性研究中剂量高达1600毫克/千克体重以及亚急性研究中剂量为500毫克/千克体重时，ISTP对心脏、肾脏、子宫和睾丸等重要器官均未显示出不良反应和死亡率。急性和亚急性毒性试验均表明，异戊二烯愈创木内酯在哺乳动物系统中是安全的，可作为合成杀虫剂的有效天然替代品。
